Deep Learning-Enhanced Multimodal MRI for Real-World Differentiation of Parkinsonian Disorders
Objective: To develop and evaluate an integrated, deep learning (DL)-enhanced multimodal MRI classification model combining nigrosome-1 (N1), neuromelanin (NM), free-water DTI (FW-DTI) and morphometry (MORPHO)…Multimodal Imaging in Cervical Dystonia with Botulinum Toxin Treatment: A Pilot 5.0T MRI and 99mTc-MIBI SPECT/CT Study
Objective: To comprehensively investigate structural, vascular, and metabolic alterations in cervical dystonia (CD) patients using ultra-high-field 5.0T magnetic resonance imaging (MRI) and 99mTc-MIBI SPECT/CT. Background:…Cholinergic Pathway Degeneration Predicts Differential Phenoconversion to Synucleinopathies in Idiopathic REM Sleep Behavior Disorder
Objective: This cross-sectional and longitudinal study aimed to elucidate the pattern of cholinergic white matter pathway degeneration underlying the phenoconversion trajectories in iRBD patients. Background:…DTI-ALPS Insights into Glymphatic Dynamics and Neurovascular Changes in Parkinson’s Disease
Objective: To investigate glymphatic activity, structural small vessel disease (SVD) markers, and white matter microstructure in Parkinson’s disease (PD) patients, and to explore their associations…Prospective Comparison of Volumetric and Diffusion MRI Biomarkers for Multiple System Atrophy
Objective: We aimed to develop new imaging biomarkers allowing objective monitoring of early Multiple System Atrophy (MSA) progression, which could improve outcome definition for future…Data-driven Longitudinal Trajectories of Hippocampal Volume in Parkinson’s Disease and Across the Neurodegenerative Disease Spectrum
Objective: To elucidate hippocampal (HP) volume trajectories in Parkinson disease (PD) and across the neurodegenerative disease (NDD) spectrum. Background: HP volume is a critical neuroimaging…Diagnostic Odyssey in L-2-Hydroxyglutaric Aciduria: A Case with Progressive Cerebellar and Extrapyramidal Movement Disorder
Objective: To highlight the evolution of movement disorder phenotype and diagnostic challenges in a child with L-2-hydroxyglutaric aciduria (L2HGA). Background: L2HGA is a rare autosomal-recessive…Neuromelanin-Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson’s Disease
Objective: To quantify associations between neuromelanin-sensitive MRI (NM-MRI) metrics and clinical severity and cumulative disease burden markers in Parkinson’s disease (PD). Background: NM-MRI visualises neuromelanin-containing…Spatiotemporal Trajectories of Plasma Biomarkers and Diffusion MRI Metrics in Parkinson’s Disease
Objective: To investigate the spatiotemporal dynamics of multimodal biomarkers and their role in early prediction of cognitive decline. Background: Cognitive impairment is a major source…Dynamic and Multimodal Prediction of Phenoconversion to Cerebellar Multiple Sytem Atrophy among Sporadic Late-Onset Cerebellar Ataxia
Objective: To dynamically predict phenoconversion from a sporadic late-onset cerebellar ataxia (SLOCA) phenotype to MSA-C. Background: Cerebellar multiple system atrophy (MSA-C) is diagnosed according to…
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