Evaluating Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 as Radiographic Metrics to Differentiate Progressive Supranuclear Palsy (PSP) from Normal Pressure Hydrocephalus (NPH)
Objective: We analyze the discriminatory diagnostic value of the Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 in progressive supranuclear palsy (PSP) and normal pressure…DTI-ALPS index and its association with dopamine loss, brain metabolism, and motor and cognitive manifestations in Parkinson’s disease
Objective: This study aimed to investigate the clinical relevance of glymphatic dysfunction in Parkinson's disease (PD) by integrating the diffusion tensor imaging (DTI) analysis along…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Revisiting Prodromal Diagnostic Criteria in MSA: The Need for Early MRI-Based Diagnosis
Objective: This prospective cohort study investigated the role of neuroimaging for the early and accurate identification of multiple system atrophy (MSA) in patients with indeterminate…Factors Associated with Efficacy and Safety of Unilateral Thalamic MRgFUS in Essential Tremor: A Single-Center Cohort Study
Objective: To identify factors associated with treatment efficacy and safety of unilateral thalamic magnetic resonance-guided focused ultrasound (MRgFUS) in patients with essential tremor (ET). Background:…Contribution of blood lipid profile to long-term outcome in idiopathic normal pressure hydrocephalus
Objective: Here, we outlined the blood lipid profile, including derived indices of metabolic dyshomeostasis, in iNPH patients, and investigated relationships with brain MRI-based pathology markers,…Beyond Diagnosis: Putaminal ADC Hyperintensity and Infratentorial Signs Reflect Motor Severity in MSA
Objective: To clarify the clinical significance of neuroimaging markers in multiple system atrophy (MSA) by (1) examining concordance among putaminal MRI markers across sequences, (2)…Sex Differences in Vascular Burden, Neurodegeneration, and Clinical Progression in Progressive Supranuclear Palsy Richardson Syndrome
Objective: To examine sex differences in cardiovascular risk, white matter hyperintensities (WMH), and neurodegeneration, and to determine their relationship with clinical progression in progressive supranuclear…Emerging Roles for Imaging Techniques in Differentiating Underlying Pathologies in Corticobasal Syndrome
Objective: This review evaluates limitations in differentiating underlying pathologies in Corticobasal syndrome (CBS). We summarize available evidence on clinical features, imaging and fluid biomarkers and…Comparing Deep Brain Stimulation and MRI-Guided Focused Ultrasound Thalamotomy for Essential Tremor: A Single-Center, 1-Year Observational Study
Objective: To compare outcomes of Deep Brain Stimulation (DBS) and Magnetic Resonance Guided Focused Ultrasound (MRgFUS) in the treatment of Essential Tremor (ET). Background: ET…
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