Sex-Specific White Matter Correlates of Neuropsychological Measures in Parkinson’s disease with Mild Cognitive Impairment
Objective: To identify sex-specific white-matter (WM) correlates of neuropsychological measures in Parkinson’s disease (PD) with mild cognitive impairment (MCI). Background: Neuropsychological measures of executive function…Does neurodegeneration of the noradrenergic locus coeruleus follow a spatial gradient in Parkinson’s disease?
Objective: To map degeneration of the locus coeruleus in Parkinson’s disease in-vivo using ultra-high field MRI. Background: Parkinson’s disease (PD) causes degeneration of dopaminergic neurons…Increased free-water in the substantia nigra in idiopathic REM sleep behaviour disorder
Objective: In this study, we tested the hypothesis that free water is elevated in the posterior substantia nigra of idiopathic rapid eye movement sleep behaviour…White matter and cognition in Parkinson’s disease
Objective: Examine whether a recently developed MRI biomarker intended to assess cerebrovascular small vessel disease, peak width of skeletonized mean diffusivity (PSMD)[1], predicts cognitive decline…Sex differences in brain and cognition in de novo PD patients
Objective: We aimed to investigate sex differences in brain atrophy and cognition in PD de novo patients through MRI subcortical volumetry and cortical thickness (CTh).…Locus coeruleus volume is reduced in Parkinson disease-related orthostatic hypotension.
Objective: To test whether structural pathology of the locus coeruleus (LC) is associated with orthostatic hypotension (OH) in Parkinson disease (PD). Background: OH is an…Hot cross bun sign in progressive ataxia with ELVOL4 mutation
Objective: To describe a case of progressive gait abnormalities and bulbar dysfunction which was associated with genetic mutation and neuroimaging findings representative of spinocerebellar ataxia…Substantia nigra pars compacta integrity is associated with DRT-related motor symptom improvement in Parkinson’s disease
Objective: To study the correlation between substantia nigra white matter integrity and response of motor symptoms to dopamine replacement therapy (DRT) in Parkinson’s disease (PD).…Developing 31-phosphorus magnetic resonance spectroscopy (31P-MRS) as an imaging biomarker to identify mitochondrial dysfunction in Parkinson’s disease
Objective: To determine if 31P-MRS can identify mitochondrial dysfunction in-vivo and if this correlates with in-vitro measures of mitochondrial function obtained from patient derived fibroblasts…Brain MRI morphological changes in different self-reported sleep disturbances in PD patients
Objective: Our study explored associations between a variety of sleep-related problems and grey matter alterations in PD. Background: Sleep disturbance is a common non-motor feature…
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