Locus coeruleus volume is reduced in Parkinson disease-related orthostatic hypotension.
Objective: To test whether structural pathology of the locus coeruleus (LC) is associated with orthostatic hypotension (OH) in Parkinson disease (PD). Background: OH is an…Hot cross bun sign in progressive ataxia with ELVOL4 mutation
Objective: To describe a case of progressive gait abnormalities and bulbar dysfunction which was associated with genetic mutation and neuroimaging findings representative of spinocerebellar ataxia…Substantia nigra pars compacta integrity is associated with DRT-related motor symptom improvement in Parkinson’s disease
Objective: To study the correlation between substantia nigra white matter integrity and response of motor symptoms to dopamine replacement therapy (DRT) in Parkinson’s disease (PD).…Developing 31-phosphorus magnetic resonance spectroscopy (31P-MRS) as an imaging biomarker to identify mitochondrial dysfunction in Parkinson’s disease
Objective: To determine if 31P-MRS can identify mitochondrial dysfunction in-vivo and if this correlates with in-vitro measures of mitochondrial function obtained from patient derived fibroblasts…Brain MRI morphological changes in different self-reported sleep disturbances in PD patients
Objective: Our study explored associations between a variety of sleep-related problems and grey matter alterations in PD. Background: Sleep disturbance is a common non-motor feature…Brain MRI Cortical Atrophy correlation to clinical onset in Huntington’s Disease
Objective: To describe brain Magnetic Resonance Imaging (MRI) characteristics in Latin American individuals with Huntington's Disease (HD) and to correlate them to major symptom at…Cortical microstructural alterations are more sensitive than morphology changes to cortical degeneration in Parkinson’s disease with mild cognitive impairment
Objective: To compare the sensitivity of detection cortical degenerative changes in patients with Parkinson’s disease (PD) and mild cognitive impairment (MCI) between the diffusion magnetic…Resting state functional connectivity networks related to MDS-UPDRS motor outcomes in Parkinson’s Disease
Objective: Investigate the functional connectivity network pairs associated with the motor symptoms in people with Parkinson’s disease (pwPD). Background: PD is a neurodegenerative disorder primarily…Total cerebral small vessel score associated with Hoehn and Yahr stages in Parkinson’s disease
Objective: To evaluate the total cerebral small vessel disease (CSVD) score in patients with Parkinson’s disease at different stages and its related factors. Background: Parkinson’s…Evolving inclusion criteria in early manifest Huntington’s disease (HD) to address striatal atrophy: Lessons from HD-GeneTRX-1, the first gene therapy trial
Objective: To describe the early screening experience and evidence-based adaptations to the inclusion criteria for HD-GeneTRX-1 (NCT04120493). Background: AMT-130 is an AAV5-based gene therapy intended…
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