The involvement of primary olfactory cortex in olfactory deficits in early-stage Parkinson’s disease
Objective: To determine if the primary olfactory cortex (POC) is involved in the olfactory deficits in early-stage Parkinson’s disease (PD) using functional magnetic resonance imaging (fMRI)…An evaluation of the diagnostic utility of radiological biomarkers in PSP
Objective: To critically evaluate the degree to which structural and molecular radiologic metrics fulfill criteria for diagnostic biomarkers of progressive supranuclear palsy (PSP). Background: PSP…Gray Matter Density in Essential Tremor: A Lobule by Lobule Analysis of the Cerebellum
Objective: Our hypothesis was that regional differences in cerebellar gray matter (GM) density may better distinguish essential tremor (ET) cases from controls. Background: The pathophysiological…Presence of abnormalities on structural MRI associate with faster disease progression in multiple system atrophy
Objective: To identify MRI markers that are associated with more rapid clinical progression in multiple system atrophy (MSA) Background: The rate of clinical progression in…Writing training enhances neural connectivity in Parkinson’s patients with micrographia
Objective: To study network interactions of patients with Parkinson’s disease (PD) and healthy controls (CT) during handwriting with and without external visual cues and to…Prospective Analysis of Morphological Markers of Development of Impulsive Compulsive Behaviors in De Novo Parkinson’s Disease
Objective: Aim of this study was to determine whether structural imaging features present at disease onset or over disease course predict the development of ICB…Diffusion-Weighted MRI discriminates Parkinson´s Disease from the Parkinsonian Variant of Multiple System Atrophy: a Meta-analysis
Objective: A systematic review and meta-analysis was performed to evaluate the diagnostic accuracy of DWI in the differential diagnosis of the parkinsonian variant of multiple…A case report: a primary progressive multiple sclerosis (PPMS) with adolescent-onset of progressive cerebellar ataxia
Objective: To report a 26 year-old female with progressive cerebellar ataxia for 12 years diagnosed to have primary progressive multiple sclerosis (PPMS). Background: Multiple sclerosis (MS) is a kind of CNS demyelinating disease. About 15% MS patients have a progressive course without a relapsing course. These patients are considered to have PPMS. It often presented a progressive neurological problem--such as lateralizing weakness, or numbness in the legs. Cerebellar ataxia as primary symptom is less frequent in PPMS and it's usually diagnosed in their 40-60 years at age. Here we present a case with adolescent-onset PPMS presenting progressive cerebellar ataxic syndrome. Methods: A 26 year-old female Taiwanese presented with 12 years of progressive ataxic gait. She denied relapses and remissions of symptoms. There were no mental decline, involuntary movements, muscle hypertrophy or abnormality in hearing or vision. She had no associated family history or consanguineous parents. Physical examination revealed dysarthria, dysmetria/intentional tremor and dysdiadochokinesia in four limbs and bilateral extensor plantar response. In addition, she had normal tendon reflexes, intact sensory function and negative Romberg test without parkinsonian features. Her gait was wide-based. Results: On investigation, CBC, lipid profile, LFT, chest X-ray, serum electrolytes, ECG, EEG and NCV showed normal results. VEP study were abnormal. The brain and cervical spine MRI showed no significant cerebellar atrophy or myelopathy. Instead, FLAIR-weighted imaging showed diffuse plaques in brainstem and cerebral white matters with a predilection for periventricular white matter with the major axes perpendicular to the ventricular surface (Dawson’s fingers). Besides, the CSF study revealed oligoclonal banding and elevation of IgG index. She had normal serum copper and ceruloplasmin levels and plasma very long-chain fatty acids (VLCFA) analysis. The genetic testing for spinocerebellar ataxia ( SCA1, 2, 3, 6, 7 and 17) is negative. In view of progressive ataxia with diffuse white matter lesions, a diagnosis of PPMS was made. Conclusions: PPMS can be a etiology in adolescent patient with progressive ataxic syndrome. Brain MRI is a better tool for detecting cerebral white matter lesions compared to CT in differential diagnosis of progressive ataxia. References:…Brain iron accumulation in Wilson disease measured by quantitative susceptibility mapping
Objective: To investigate whether cerebral iron deposits in Wilson disease (WD) patients are associated with decreased serum ceruloplasmin oxidase activity and/or clinical severity. Background:…Longitudinal white matter microstructural change in Parkinson’s disease
Objective: To map regional differences in rates of change in diffusion tensor imaging (DTI)-based measures of brain white matter microstructural integrity between Parkinson (PD) patients and…
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