Impaired stress-induced mitophagy in parkinsonian LRRK2(R1441G) knockin mutant mice
Objective: 1. Morphological changes and accumulation of ubiquitinated mitochondria in the striatum of aged leucine-rich-repeat kinase 2 (LRRK2)R1441G knockin mutant mice (Liu et al., 2014,…Citrus extract A protects dopaminergic neuron by modulating mitochondrial respiration and reactive oxygen species
Objective: This study aims to validate the protective effect of citrus extract A (CEA) against loss of dopamine neurons in PD by dual targeting of…CR6-interacting factor1 Deficiency in Dopamine Neurons Triggers Early-onset Parkinsonism in Mice
Objective: One candidate is CR6-interacting factor1 (CRIF1), which controls translation and membrane insertion of 13 mitochondrial proteins involved in oxidative phosphorylation. Here we determined the…Inhibition of mitochondrial complex I synthesis by chloramphenicol mitigates dopaminergic neuronal cell loss in PQ-induced parkinsonism
Objective: To find the potent drug for prevention of PD, we screened with above 1000 drugs in the PQ treated cells which currently used drug…Enteric neurons reveal substantial in vivo mitochondrial changes in Parkinson’s disease
Objective: Study in vivo mitochondrial and ganglionic morphometrics of enteric neurons in Parkinson's disease. Background: While well established in autopsy studies, the crucial role of…Evaluation of the role of oxidative stress in Parkinson’s disease and Parkinson plus syndrome
Objective: To evaluate the role of oxidative stress in peripheral blood in patients with Parkinson's disease (PD) and Parkinson plus syndrome (PPS). Background: Slight excess…Increased cerebrospinal fluid lactate levels in Parkison’s disease: Is it a proof of mitochondrial inefficiency?
Objective: The aim of the present study was to investigate the impairment of neuronal energy metabolism, as measured by means of cerebrospinal fluid (CSF) lactate…Beyond initial clinical phenotype of Madelung disease: Myoclonus, gait disorder and multisystem involvement led to genetic diagnosis
Objective: To report the clinical phenotype of an uncommon hereditary systemic disease with slowly progressive gait and movement disorder with genetic identification of two concurrent…Epigenome-wide association study of Parkinson’s disease
Objective: To identify gene-specific DNA methylation associated with Parkinson's disease (PD). Background: There is a growing interest in the role of epigenetic DNA methylation (DNAm)…Fast and simple non-invasive screening tool for mitochondrial changes in Huntington’s disease
Objective: To use Complex I and Complex IV Human Protein Quantity Dipstick Assay Kits to analyse mitochondrial changes in buccal epithelial cells of patients with…
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