Marked reduction of energy supply due to levodopa treatment in patients with Parkinson’s disease and healthy controls
Objective: To investigate the influence of a standardized, placebo-controlled administration of levodopa on cerebral bioenergetics in patients with Parkinson’s disease (PwPD) and healthy controls (HCs).…Use of insect model to study Parkinson’s disease pathophysiology by inducing GSH-depletion and behavioral deficits among larvae: Evidences of ameliorative properties of phytoconstituents
Objective: The purpose of the study is to establish an all-around model for Parkinson's disease using Drosophila melanogaster, the fruit-fly in order to understand behavioral…The induction of mitochondrial damage by alpha synuclein In Parkinson’s disease.
Objective: Alpha synuclein aggregation have been indicted in the process of neuronal cell loss in Parkinson's disease; however, there have been several hypothesis to explain…Movement disorders in children with neurometabolic and neurodegenerative disorders: A single-center prospective study
Objective: To analyze the prevalence, patterns and severity of movement disorders in children with genetically proven neurometabolic and neurodegenerative diseases. Background: Movement disorders are often…Effects of a small molecule angiotensin IV analog on Huntington’s disease animal model
Objective: The present study was designed to test if N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (AngIV-6a), an angiotensin IV analog, could attenuate 3-nitropropionic acid-induced Huntington’s disease-like symptoms in…Generalized dystonia and spasticity: The fault in the mitochondria
Objective: To analyze the pattern of movement disorder in a child with mitochondrial respiratory chain disorder Background: Secondary movement disorders are often a clue to…Impaired CaMKII/ERK activation in mouse mutant LRRK2 R1441G fibroblasts was associated with reduced mitochondrial calcium store and efflux in response to depolarization stress
Objective: To determine the molecular link of LRRK2R1441G mutation to impaired CaMKII/ERK signaling under mitochondrial depolarization stress using mutant mouse embryonic fibroblast (MEF) model of…Effectiveness of Combined tDCS and tNIRS on Motor Performance in Parkinson’s Disease – A Single Case Study
Objective: The aim of the current study was to evaluate the synergistic effects of combining transcranial near infrared light stimulation (tNIRS) and transcranial direct current stimulation…Functional validation of a mitochondria-specific polygenic risk score in patient-based models for stratification of idiopathic Parkinson’s disease
Objective: The overall objective of this project is to gain essential knowledge on the contribution of genetic variability in nuclear-encoded mitochondrial proteins to idiopathic Parkinson’s…Metabolic Biomarkers of Parkinson’s Disease in Peripheral Tissue
Objective: The goal of this study was to use magnetic resonance spectroscopy (MRS) to test whether muscles of individuals with Parkinson’s disease (PD) possess a…
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