Boosting Clinical Trial Power in Parkinson’s Disease with AI-Generated Digital Twins
Objective: To evaluate the incorporation of prognostic digital twins to enhance traditional clinical trials in Parkinson’s Disease (PD) for disease modifying therapies. We assess the…Remote monitoring of upper limb function in Huntington’s disease using a wearable sensor
Objective: To develop and evaluate machine learning models to identify patients with Huntington's disease (HD) and to predict their symptom severity related to upper limb…Neurologic Music Therapy (NMT) and Non-Invasive Stimulation for Upper Extremity Performance in Patients with Corticobasal Syndrome (CBS)
Objective: To investigate if NMT with or without non-invasive brain stimulation can improve upper limb performance in patients with corticobasal syndrome Background: Previous research suggests…A randomized, phase 2a, double-blind, placebo-controlled clinical trial with NE3107 adjunctive to carbidopa/levodopa in patients with Parkinson’s disease
Objective: To evaluate the motor effects of NE3107 treatment in patients with levodopa-treated Parkinson’s disease (PD) experiencing motor fluctuations. Background: NE3107 is an oral, blood-brain…Stability and predictability of motor symptom control in patients with advanced Parkinson’s disease (aPD) receiving continuous subcutaneous foslevodopa/foscarbidopa (LDP/CDP)
Objective: To evaluate temporal changes in motor states (OFF and ON without troublesome dyskinesia [TD; good ON]) throughout the waking day in patients with aPD…Nocturnal behavior of people with Parkinson’s disease
Objective: Compare the nocturnal energy expenditure (kcal) and activity behavior of people with PD using a real-time wearable sensor, and determine whether these outcomes differed…Influence of Cognitive Function on Obstacle-Crossing Performance in People with Parkinson’s Disease: A Cross-Sectional Study
Objective: This study investigated the influence of cognitive function on obstacle crossing performance in people with Parkinson's disease (PD). Background: Obstacle-crossing is a complex motor…Potential role of Alpha-synuclein levels in Platelets in GBA-related PD
Objective: Identification of a blood biomarker to predict PD diagnosis or to monitor the disease progression. Background: Previous evidence suggests differences in systemic alpha-synuclein levels…Effects of NE3107 anti-inflammatory treatment on motor activity and neurodegenerative features of Parkinson’s disease in a marmoset monkey model
Objective: To demonstrate the effects of an oral, anti-inflammatory agent, NE3107, on motor activity, levodopa-induced dyskinesia (LID) induction, and neuron survival in a marmoset model…Association between fine motor function and brain structure: Findings from the population-based Rhineland Study
Objective: To examine the relation between brain structure and fine motor function across adult lifespan in a large cohort study. Background: Decreased fine motor function…
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