Under three seconds: Objective speech markers of ataxia in Multiple Sclerosis
Objective: To examine the relationship between objective markers of speech motor control, disease severity and ataxia. Background: Mild dysarthria is a common symptom of Multiple…Movement Disorders secondary to Spinal Cord Demyelination: an Evolving Spectrum
Objective: To describe the spectrum of movement disorders that result from spinal cord demyelination. Background: Spinal movement disorders (SMDs) secondary to cord demyelination are not…Movement Disorders in Demyelinating Diseases: a retrospective review from a tertiary academic center.
Objective: To review the prevalence of movement disorders (MD) in patients with demyelinating diseases (DD) treated at a tertiary academic center and to characterize their therapeutic response…A case of Dementia with Lewy Bodies Co-Occuring with Multiple Sclerosis
Objective: To describe a unique case of Dementia with Lewy bodies (DLB) co-occurrence with Multiple Sclerosis (MS) Background: Various movement disorders have been described in…A case report: a primary progressive multiple sclerosis (PPMS) with adolescent-onset of progressive cerebellar ataxia
Objective: To report a 26 year-old female with progressive cerebellar ataxia for 12 years diagnosed to have primary progressive multiple sclerosis (PPMS). Background: Multiple sclerosis (MS) is a kind of CNS demyelinating disease. About 15% MS patients have a progressive course without a relapsing course. These patients are considered to have PPMS. It often presented a progressive neurological problem--such as lateralizing weakness, or numbness in the legs. Cerebellar ataxia as primary symptom is less frequent in PPMS and it's usually diagnosed in their 40-60 years at age. Here we present a case with adolescent-onset PPMS presenting progressive cerebellar ataxic syndrome. Methods: A 26 year-old female Taiwanese presented with 12 years of progressive ataxic gait. She denied relapses and remissions of symptoms. There were no mental decline, involuntary movements, muscle hypertrophy or abnormality in hearing or vision. She had no associated family history or consanguineous parents. Physical examination revealed dysarthria, dysmetria/intentional tremor and dysdiadochokinesia in four limbs and bilateral extensor plantar response. In addition, she had normal tendon reflexes, intact sensory function and negative Romberg test without parkinsonian features. Her gait was wide-based. Results: On investigation, CBC, lipid profile, LFT, chest X-ray, serum electrolytes, ECG, EEG and NCV showed normal results. VEP study were abnormal. The brain and cervical spine MRI showed no significant cerebellar atrophy or myelopathy. Instead, FLAIR-weighted imaging showed diffuse plaques in brainstem and cerebral white matters with a predilection for periventricular white matter with the major axes perpendicular to the ventricular surface (Dawson’s fingers). Besides, the CSF study revealed oligoclonal banding and elevation of IgG index. She had normal serum copper and ceruloplasmin levels and plasma very long-chain fatty acids (VLCFA) analysis. The genetic testing for spinocerebellar ataxia ( SCA1, 2, 3, 6, 7 and 17) is negative. In view of progressive ataxia with diffuse white matter lesions, a diagnosis of PPMS was made. Conclusions: PPMS can be a etiology in adolescent patient with progressive ataxic syndrome. Brain MRI is a better tool for detecting cerebral white matter lesions compared to CT in differential diagnosis of progressive ataxia. References:…VOP/ZI deep brain stimulation for the relief of tremor in multiple sclerosis
Objective: To evaluate the therapeutic effect of electrical chronic stimulation of ventralis oralis posterior and zona incerta (VOP/ZI) in 3 subjects affected by severely disabling…Core set of measures of balance for people with multiple sclerosis and cerebellar ataxia
Objective: To examine the reliability, validity and interpretability of four measures in assessing the severity of balance dysfunction and short term treatment benefits on balance…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.