A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity
Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…Sodium butyrate attenuates rotenone-induced neurodegeneration via enhancing autophagy and preventing α-synuclein aggregation
Objective: To investigate whether sodium butyrate (NaB) could enhance autophagy and thus exert a neuroprotective effect through the modulation of α-synuclein in animal models of…Beneficial effect of L-theanine against 3-nitropropionic acid induced neurotoxicity in rats: Possible role of neurotransmitters and nitric oxide
Objective: The present study was intended to investigate the effect of L-theanine against 3-NP induced striatal toxicity. Background: L-theanine is unique amino acid which readily…Piperine potentiates neuroprotective effect of curcumin in MPTP model of Parkinson’s disease in rats: Impact on neurochemical modulation
Objective: (1) Curcumin is well tolerated phenolic compound used for CNS disorder but problem is its low oral bioavailability and (2) Piperine is combined to…Participation in cognitively-stimulating activities and computer use are associated with better cognitive performance in Parkinson’s disease independent from nigrostriatal dopaminergic and cortical cholinergic degenerations
Objective: To investigate the relationship between times spent with cognitively stimulating activities and cognitive functions in Parkinson's disease (PD) while accounting for the degree of…Targeting PDE7 by the small molecule S14: A potential disease-modifying Parkinson�s disease therapy ready to start clinical trials
Objective: The main goal of this work is the regulatory chemical, pharmaceutical and toxicological development of S14, a new therapeutic class for the potential treatment…The role and underlying mechanisms of BAG3 in regulating autophagy in PC12 cells
Objective: To detect the role of Bcl-2-associated athanogene 3 (BAG3) in regulating autophagy in PC12 cells and explore the underlying mechanisms of it. Background: Increasing…A computational model of iron transport between the blood circulation and the brain
Objective: To create a mechanistic computational model of iron transport between the circulation and brain, permitting in silico investigation of homeostatic regulation of iron at…Progress in the development of small molecules based on the coumarin core as multifunctional neuroprotective agents
Objective: Taking into account the background of our research group and the knowledge that MAO and ChE activity generates ROS that cause neuronal cell death,…Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.