MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Nigrostriatal dopaminergic synapse deficiency"

  • 2019 International Congress

    Glabellar tap predicts dopamine transporter deficiency in parkinsonism

    S. Nuuttila, J. Joutsa, M. Eklund, E. Jaakkola, E. Mäkinen, T. Noponen, T. Ihalainen, F. Scheperjans, V. Kaasinen (Turku, Finland)

    Objective: The objective of this study was to investigate the association between glabellar tap findings with nigrostriatal dopamine function in patients with unclear parkinsonism. Background:…
  • 2019 International Congress

    Correlation between striatal CIT uptake and Mini-Mental State Examination in Parkinson’s disease

    OD. Kwon, SG. Park, SB. Lee, JA. Park (Daegu, Republic of Korea)

    Objective: This study was performed to identify any relationship between the amount of decline of receptor uptake of CIT and Mini-Mental State Examination(MMSE) score in…
  • 2019 International Congress

    Therapeutic intervention of LRRK2 kinase inhibitors in Vps35 p.D620N Parkinsonism

    I. Tatarnikov, J. Follett, J. Fox, M. Farrer (Vancouver, BC, Canada)

    Objective: To explore the therapeutic potential of LRRK2 kinase inhibitors in a Vps35 p.D620N mouse model of Parkinsonsim. Background: The discovery of a missense mutation, Vps35 p.D620N…
  • 2019 International Congress

    Is DAT imaging abnormality in Normal Pressure Hydrocephalus always suggestive of degeneration? Evidences from three cases

    C. Del Gamba, A. Bruno, D. Frosini, D. Volterrani, N. Benedetto, C. Pacchetti, P. Perrini, M. Cosottini, U. Bonuccelli, R. Ceravolo (Pisa, Italy)

    Objective: To study parkinsonism in iNPH, in order to shed light on its pathogenesis, understand potential overlap with idiopathic parkinsonismsand its impact on the clinical outcome.…
  • 2018 International Congress

    Correlation between cerebral perfusion and striatal dopamine transporter activity by dual SPECT study in Parkinsonian syndromes

    Y. Nakano, S. Hirano, K. Kojima, H. Li, A. Ishikawa, T. Sakurai, H. Tai, H. Mukai, T. Horikoshi, T. Uno, S. Kuwabara (Chiba, Japan)

    Objective: We aimed to investigate the correlations between brain perfusion and striatal dopamine transporter (DAT) activity in parkinsonian syndromes and to characterize the difference in…
  • 2018 International Congress

    Effect of striatal dopamine depletion on cognition in de novo Parkinson’s disease

    H. Jeong, S. Chung, J. Oh, J. Kim, P. Lee (Seoul, Republic of Korea)

    Objective: To investigate the relationship between the sub-regional pattern of striatal dopamine depletion and cognitive impairment in early-stage Parkinson’s disease (PD), and determine the effect…
  • 2017 International Congress

    U-shaped dopamine resting state connectivity response function related to working memory performance in adults with early-stage Parkinson’s disease

    A. Metcalfe, S. Udow, H. Sharmarke, Z. Shirzadi, D. Long, S. Duff-Canning, C. Marras, A. Lang, B. MacIntosh, M. Masellis (Toronto, ON, Canada)

    Objective: Appraise how cognitive performance and neural response is affected by nigrostriatal denervation in early-stage Parkinson’s disease (PD). Background: Cognitive dysfunction in PD is heterogeneous…
  • 2017 International Congress

    Correlation analysis between dopamine release in striatal sub-regions and motor impairment in Parkinson’s disease subjects

    I. Klyuzhin, M. Sacheli, N. Vafai, E. Shahinfard, B. Lakhani, J. Neva, J. Fu, J. McKenzie, N. Neilson, K. Dinelle, L. Boyd, A. Stoessl, V. Sossi (Vancouver, BC, Canada)

    Objective: To investigate correlations between the sub-regional dopamine release (DR) in the striatum of Parkinson’s disease (PD) subjects and sub-components of motor performance evaluated according…
  • 2017 International Congress

    Persistent L-Dopa Responsive Hemiparkinsonism After Cryptococcoal Meningoencephalitis in an Immunocompetent Man

    G. Fabiani, R. Filho, F. Germiniani, H. Teive (Curitiba, Brazil)

    Objective: Our objective is to report a case of persistent L-dopa responsive hemiparkinsonism after Cryptococcal meningoencephalitis in an immunocompetent man. Background: Fungal infections of the CNS are…
  • 2017 International Congress

    99mTc -TRODAT- 1 SPECT SHOWING DOPAMINERGIC DEFICIENCY IN A PATIENT WITH SPINOCEREBELLAR ATAXIA TYPE 10 AND PARKINSONISM.

    G. Fabiani, R. Filho, T. Ashizawa, H. Teive (Curitiba, Brazil)

    Objective: In this report, we describe a Brazilian patient with SCA10, with parkinsonism, with a 99Tc - TRODAT-1 SPECT demonstrating dopaminergic deficiency. Background: Spinocerebellar ataxia…
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