Path to Prevention (P2P) – Developing a Prodromal PD Progression Biomarker Program
Objective: The overall objective of the Path to Prevention (P2P) initiative is to identify clinical, imaging, and biologic markers of progression during the prodromal phase…Cognitive Processes That Indirectly Effect Olfactory Dysfunction in Parkinson’s Disease
Objective: Investigate cognitive mechanisms contributing to olfactory dysfunction in Parkinson’s disease. Background: Accurate early diagnosis of Parkinson’s disease is hampered by its long prodromal period…Olfactory dysfunction predicting cognition
Objective: To investigate the relationship between impairment in smell and cognitive function among older adults using both self-report and objective measurement of olfactory function. Background:…A53T mutant human α-synuclein BAC transgenic mice as a model for Parkinson’s disease
Objective: The aim of this study is to create mouse models reproducing the course of PD pathology and symptoms. Background: Parkinson's disease (PD) is a…Olfactory impairment correlates strongly with limbic blood flow in patients with Parkinson’s disease
Objective: To examine the cerebral blood flow pattern of patients of Parkinson's disease with olfactory disorders, and to investigate the correlation between olfactory impairment and…Olfactory dysfunction, sleep disturbances, neuronal loss, and regional brain atrophy in an inducible mouse model of Alpha-Synucleinopathy
Objective: The objective of this work is to develop a unique mouse model of spreading α-synucleinopathy to accelerate the development of novel disease-modifying treatments for…Association of Olfaction dysfunction with Brain Microstructure in Prodromal Parkinson disease
Objective: Investigating the association between olfactory dysfunction and connectometry patterns in UPSIT-matched prodromal and PD patients. Background: Parkinson’s disease (PD) is a heterogeneous neurodegenerative disease…Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson’s disease
Objective: To identify dopamine transporter status of corpus striatum and thalamus using magnetic resonance imaging-guided spatial normalization method in patients with PD according to olfactory…Clinical and imaging progression in the PARS cohort: Results from 6 years of observation
Objective: The goal of the Parkinson Associated Risk Syndrome (PARS) study is to explore the clinical and biomarker trajectory of individuals in the pre-motor phase…Diffusion tensor imaging of olfactory tract in Parkinson’s disease
Objective: We investigated the possible relationships among olfactory impairment and alterations in diffusion tensor imaging (DTI) of olfactory tracts, comparing a cohort of patients with…
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