Prevalence of Autonomic dysfunction and its correlation with Clinico-imageological features in Parkinson’s Disease
Objective: To study the prevalence of autonomic dysfunction and to correlate with clinico-imageological features and to assess the impact of autonomic dysfunction on quality of…Putaminal dopamine depletion in de novo Parkinson’s disease predicts future development of wearing-off
Objective: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson’s disease.…Cardiac sympathetic denervation can predict the wearing-off phenomenon in patients with Parkinson’s disease
Objective: To investigate whether cardiac sympathetic denervation increases the risk of the early wearing-off phenomenon in Parkinson's disease (PD). Background: Recent studies have suggested that…Subthalamic theta oscillations in Parkinson’s disease
Objective: Identifying the effect of dopamine on subthalamic theta oscillations in Parkinson’s disease (PD). Background: Understanding the underlying electrophysiological alterations in PD is essential for…Characterization of the gastrointestinal dysfunction in mice overexpressing the human mutation (A53T) of alpha-synuclein
Objective: The aim of this study was to determine if mice overexpressing the human mutation of alpha-synuclein develop gastrointestinal (GI) dysfunction, and to understand the…Autonomic Dysfunction in Parkinson’s Disease: Role of New Surrogate Markers
Objective: The physiology of respiration is modulated by autonomic efferent neurons and circulating hormones. A continuous ambulatory monitoring of various respiratory parameters helps in early…Investigation of the incidences of non-motor symptoms in first-degree relatives and the spouses of patients with Parkinson’s disease
Objective: The first-degree relatives of PD patients (such as siblings) and the spouses living together for many years do not have classic motor symptoms. However,…A Study of Pain in Parkinson’s Disease
Objective: To study the prevalence, type and severity of pain in patients with Parkinson’s disease. Background: Pain is one of the recognised non-motor symptoms in…Experimental rotenone model
Objective: To evaluat rotene model of parkinsonian syndrome in rats. Background: Rotenone is of highly lipophilic substances that can freely enter hematoencephalic barrier through and…Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease
Objective: To characterize the firing rate and pattern of oscillatory neurons in basal ganglia and thalamus in patients with Parkinson’s disease (PD). Background: The cardinal…
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