Dissecting molecular signatures of X-linked dystonia-parkinsonism (XDP) through integrative genomics studies
Objective: To determine the causal locus and functional mechanism associated with XDP using integrative genomics methods in patient-derived and genome-edited induced pluripotent stem cell (iPSC)…Novel biomarkers of autonomic regulation and sleep in Parkinson’s Disease derived from Network Physiology
Objective: Utilize a novel Network Physiology approach to identify new biomarkers of Parkinson’s Disease (PD) based on the dynamics on individual physiological systems, and their…Exploring the utility of the ChulaPD intelligent Parkinson’s disease car to determine naturalistic driving ability in Parkinson’s disease patients: A pilot study of 10 patients
Objective: To examine the naturalistic driving performance in PD patients compared to controls and to determine if the PD patients showed diminished abilities. Background: Competence…Neuromodulatory role of subthalamic nucleus deep brain stimulation in Parkinson’s disease patients
Objective: The aim of study was to evaluate the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on the motor disabilities and cognitive alterations in…The possibility of medicamentous correction of the lower urinary tract dysfunction in patients with Parkinson’s disease
Objective: The aim of the study was to correct the dyskinesia of the extremities, to study the efficacy and safety of drug therapy in men…Design of a Phase 3 Efficacy and Safety Trial of Accordion Pill™ Carbidopa/Levodopa for Parkinson’s Disease (PD) Patients Experiencing Motor Fluctuations
Objective: To review the design and unique features of an ongoing phase 3 trial of a gastric-retentive formulation of carbidopa/levodopa (CD/LD), the Accordion Pill™ (AP),…Levodopa Induced Orthostatic Hypotension in Parkinson’s Disease: A Single-Dose Response Study
Objective: To determine the effect and risk factors of a single dose levodopa induced OH in PD Background: Levodopa (LD) is widely recognised as the…PROtein, LEucine And vitamin D Enhancing Rehabilitation (PRO-LEADER) in patients with Parkinson’s disease or parkinsonism: A RCT
Objective: We evaluated the efficacy of a muscle-targeted nutritional support on the outcomes of a multidisciplinary intensive rehabilitation treatment (MIRT). Background: Physical rehabilitation is an…Effect of Post-Operative Symptomatic Lead Edema Associated with Subthalamic Deep Brain Stimulation On Clinical Outcomes
Objective: To assess whether development of post-operative symptomatic edema around deep brain stimulation (DBS) leads impacts clinical outcomes. Background: Post-operative symptomatic delayed edema around the…Can brittle dyskinesia be one of the causes of Twiddler syndrome in Deep Brain Stimulation?
Objective: To discuss whether brittle dyskinesia can be a cause of Twiddler syndrome. Background: Many studies have reported that the cause of Twiddler syndrome (…
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