Zonisamide improves parkinsonism in DLB patients: A randomized phase 3 trial
Objective: To verify the efficacy and safety of zonisamide (ZNS) for parkinsonism in patients with dementia with Lewy bodies (DLB). Background: DLB parkinsonism is responsive…A framework to facilitate competence in practice for Parkinson’s Disease Nurse Specialists in the United Kingdom
Objective: To determine if the current Parkinson's Disease Nurse Specialist (PDNS) competency framework 2nd Edition 2008 (1) for nurses working in the management of Parkinson's…Diagnostic potential of automated middle cerebellar peduncle volumetry in variants of multiple system atrophy
Objective: To include probabilistic information on the location of the middle cerebellar peduncle (MCP) into an existing subcortical segmentation atlas and to evaluate the diagnostic…Efficacy and safety of safinamide as a levodopa adjunct in patients with parkinson disease and motor fluctuations: A systematic review of randomized controlled trials
Objective: To assess the efficacy and safety of safinamide as an add-on therapy to levodopa in Parkinson patients. Background: Long-term use of levodopa is associated…Inhibition of HDAC4 attenuates rotenone-induced abnormal increase of α-synuclein levels and affects autophagic flux in human dopaminergic SH-SY5Y cells
Objective: To explore the effects of selective inhibition of HDAC4, on levels of α-syn and autophagy-related proteins in PD. To discuss the mechanism for the…Effects of Rock Steady Boxing on Activities of Daily Living and Motor Symptoms of Parkinson’s Disease
Objective: To determine the impact of the Rock Steady Boxing (RSB) program on Parkinson’s disease (PD). To assess the feasibility of data collection for activities…A clinical tool to ensure delivery of modern personalised medicine for Parkinson’s disease: first description of a personalised medicine checklist
Objective: To field test a clinically relevant checklist to ensure that health care professionals (HCP) are prompted to consider the various enablers of personalised medicine…Ondansetron, a highly-selective 5-HT3 receptor antagonist, alleviates L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To determine the effectiveness of selective serotonin 3 (5-HT3) receptor blockade at reducing the severity of established, and preventing the development of, dyskinesia. Background:…Impact of Age on Levodopa dosage regimes in Idiopathic Parkinson’s Disease
Objective: To assess the influence of patient age on prescribed dosage and subsequent dose escalation regimes of levodopa therapy in a cohort of people with…Eye Movement Abnormalities Correspond to Pontine Atrophy in Wilson Disease
Objective: This study aims to characterize eye movement (EM) abnormalities in Wilson´s disease (WD) and to assess their relation to clinical severity of WD and…
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