Is cognitive decline similar among Parkinson’s disease motor sub-types? A prospective study examining changes over time in gait, balance and cognition
Objective: To investigate whether changes over time in cognitive and motor functions differ across the postural instability gait difficulty (PIGD) and tremor dominant (TD) motor…Subjective visual vertical in patients with early Parkinson’s disease
Objective: To identify the changes of subjective visual vertical and any correlation between SVV and cognitive/motoric dysfunctions in Parkinson's disease. Background: Dysfunction of sensory system is…Randomize study of occurrence of Parkinson’s syndrome in patients with rheumatoid arthritis.
Objective: We aimed to study an occurrence of Parkinson’s syndrome (PS), its relationship with duration of disease and age of patients with rheumatoid arthritis. Background:…Parkinsonism through astrocytic GABA induce motor symptoms
Objective: Although reactive gliosis is a prominent feature of PD, its role in pathogenesis has remained elusive. Here we show that aberrantly synthesized GABA from reactive astrocytes tonically inhibits neighboring dopaminergic neuronal firing in SNpc, reducing dopamine production and release, leading to parkinsonian motor symptoms. Background: Parkinsonism is a clinical syndrome of movement abnormalities seen in Parkinson’s disease (PD), which has been attributed to cell-autonomous mechanism of doparminergic neuronal death in the substantia nigra pars compacta (SNpc). Methods: To identify the…The diagnostic challenges of patients with possible multiple system atrophy
Objective: The aim of the this study to review the diagnostic challenges of MSA and to evaluate the patients with different clinic types of MSA-…Neurogenic Orthostatic Hypotension Burden of Illness Patient and Caregiver Survey: Impact of Symptoms
Objective: To determine the impact of neurogenic orthostatic hypotension (nOH) on the quality of life (QoL) of patients with autonomic dysfunction and the burden on…An Objective Tool to Guide Target Selection for DBS in PD (GPi vs STN)
Objective: To create a simple tool to aid in selection of the proper target for Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD). Background: Two…Probabilistic mapping of deep brain stimulation in Parkinson’s disease.
Objective: To find the neuroanatomical origins of deep brain stimulation (DBS) induced effects using probabilistic mapping. Background: While DBS of the subthalamic nucleus (STN) and…Pathological crying induced by deep brain stimulation of the subthalamic nucleus in Parkinsons’ disease
Objective: To report on a patient with Parkinsons’ disease (PD) who developed pathologic crying (PC) following chronic deep brain stimulation (DBS) of the subthalamic nucleus…Longitudinal study of freezing of gait in patients with Parkinson’s disease
Objective: We conducted a prospective hospital based cohort study to investigate the incidence of Freezing of gait (FOG) and variables associated with onset of FOG…
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