Semi-quantitative Evaluation of Midbrain Accumulation in 123I-FP-CIT SPECT in Parkinson’s disease and Parkinsonian Syndromes
Objective: To establish a method for evaluating midbrain accumulation of 123I-FP-CIT SPECT and assess its ability to differentiate between Parkinson’s disease (PD) and Parkinsonian syndromes…Myofascial pain syndromes in parkinsonism
Objective: To study of pain syndromes in parkinsonism Background: Myofascial Pain Syndrome (MPS) is a common but underdiagnosed pain disorder in Parkinson’s disease (PD), marked…Quantifying Bradykinesia in Real-world Practice: A Clinician-friendly Video Analysis Tool for Parkinson’s Disease
Objective: To develop and validate a video-based automated analysis tool for the objective and quantitive assessment of bradykinesia in Parkinson’s disease (PD). Background: Currently, evaluating…HPRT1 Gene Mutation in a Young Male with Early Childhood Onset Seizures-Parkinsonism and Levodopa-Induced Dyskinesia: A Case Report
Objective: To report the clinical course, diagnostic evaluation, and genetic findings in a 24-year-old male with early childhood onset tremor, seizures ,bradykinesia and rigidity ,…Carbidopa/levodopa related hypotension in patients with alpha-synucleinopathies
Objective: Evaluate blood pressure response to levodopa/carbidopa in patients with synucleinopathies undergone to autonomic testing. Background: Carbidopa/levodopa is the mainstay treatment of patients with synucleinopathies,…Rethinking Parkinsonism: Limitations in Clinical Diagnosis
Objective: To highlight the limitations in clinically differentiating PD and MSA. Background: The antemortem differentiation of parkinsonian syndromes remains challenging due to overlapping symptomatology, particularly…Unveiling a rare case: Novel TBK1 variant presenting as Multiple system atrophy-like phenotype
Objective: Tumour necrosis factor NF-ƘB activator (TANK) binding kinase 1 (TBK1) is necessary for immune and inflammatory responses. Reports of TBK1 with neurodegeneration are noted…Beyond the Classic Triad: An Unusual Phenomenology of Parkinsonism in a Patient with Superficial Siderosis (SS)
Objective: To highlight the phenomenology in a complex case of superficial siderosis (SS) presenting with hearing loss, ataxia, and parkinsonism Background: SS is a rare…Impact of Cognition on Social Engagement in Community-based Older Adults with Parkinsonism
Objective: To investigate how cognition and gait influence social engagement in parkinsonism. Background: Social engagement is vital to quality of life in parkinsonism, yet the…Alpha-Synuclein Amplification Assays Utilizing Real-Time Quaking-Induced Conversion (RT-QuIC) from Non-Invasive Saliva as a Novel Diagnostic Tool for Patients with Parkinson’s Disease
Objective: The main objective is to evaluate the sensitivity of aSyn-RT-QuIC in diagnosing Parkinson's Disease (PD) from non-invasive saliva. The results will be corroborated in…
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