Integrating Parkinson’s Plus Cohorts into the Global Parkinson’s Genetics Program
Objective: To integrate Parkinson’s Plus Cohorts into the Global Parkinson’s Genetics Program (GP2) and design a dictionary of data to be collected. Background: GP2 is…Disease-related comprehensive motor pattern derived from 2D single RGB video as a biomarker for early and prodromal Parkinson disease
Objective: This study aims to develop a disease-related motor pattern from a single 2D RGB video as a biomarker for early diagnosis and monitoring of…Comparison of Age, Cognitive, Autonomic, and Motor Testing between Serotonergic vs Idiopathic REM-Sleep Behavior Disorder
Objective: To compare the age, cognitive, autonomic, and motor function of REM-Sleep Behavior Disorder (RBD) patients amongst those who believe their symptoms were triggered by…Loneliness Relates to Gait Over Other Features of Parkinsonism
Objective: To assess the relationship between loneliness and facets of parkinsonism in community-based samples. Background: Loneliness increases the risk of mortality, dementia, depression, and motor…Cross-Omics Clustering Identifies Common Molecular Patterns in Parkinson’s Disease
Objective: Uncover novel molecular signatures to define Parkinson's disease (PD) patients' clusters using multi-omics integration and evaluate clinical and neuroimaging data. Background: PD is a…The Feasibility and Practical utility of Virtual Visits for Patients with Parkinson’s disease in Different World Regions
Objective: To investigate the feasibility and efficacy of virtual visits (TM) for Parkinson's Disease (PD) compared to in-person visits in different World Health Organization (WHO)…Lysosomal network defects in parkinsonian patients carrying rare variants in lysosomal hydrolytic enzyme genes
Objective: Functional validation of rare variants of lysosomal genes potentially associated with early onset Parkinson's disease (EOPD) Background: The genetic load in EOPD is high;…Can Heterozygous Autosomal Recessive Mutations Cause Neurological Disease?
Objective: To highlight the significance of heterozygous PLA2G6 and PRKN gene mutations in causing parkinsonism. Background: We report our observations in two families with multiple…Misdiagnosing Movement Disorders on a Terciary Academic Center in the Caribbean: A Series of Cases
Objective: To report 10 movement disorder cases misdiagnosed by general neurologists as another disorder or a different category of movement disorder. Background: The misdiagnosis of…Inclusion of PSP-Parkinsonism (PSP-P) phenotype in clinical trials – power calculation
Objective: PSP-P is the second most common PSP phenotype. To facilitate its inclusion in future clinical trials, we used longitudinal data from the TAUROS study…
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