Speed and severity of toxicity induced by pre-formed α-synuclein fibrils in rat brain is enhanced by α-synuclein overexpression
Objective: To develop a physiologically relevant model of PD. Background: Intracerebral injection of pre-formed α-synuclein fibrils has emerged as an interesting tool to induce PD-like…Dysregulated macroautophagy and mitochondrial dynamics in PD with glucocerebrosidase mutations
Objective: To investigate markers of macroautophagy and mitochondrial dynamics in fibroblasts and postmortem brain of Parkinson's disease (PD) patients with glucoerebrosidase (GBA1) mutations and controls.…Diffusion tensor imaging (DTI) within the primate caudate nucleus marks dopaminergic (DA) and serotonergic (5-HT) lesions
Objective: To determine the best diffusion tensor imaging markers of dopaminergic and serotonergic lesions in the non-human primate. Background: DTI has received particular interest to…Histone deacetylase 4 is regulated by microRNA 128 in SH-SY5Y cells of Parkinson’s disease
Objective: To explore the mechanisms and regulating effects of microRNA 128 in Parkinson's disease (PD). Background: PD is the second common progressive neurodegenerative disorder characterized…Alterations in 14-3-3 protein phosphorylation as a biomarker for neurodegeneration
Objective: To examine whether 14-3-3 phosphorylation is altered in Parkinson's disease and other neurodegenerative disorders. Background: 14-3-3 proteins are a highly conserved family of proteins…Effects of age and gender on brainstem MR-planimetry
Objective: To evaluate age- and gender effects on brainstem MR-planimetric measures. (1,2). Background: Brainstem planimetry has been successfully applied to differentiate Progressive Supranuclear Palsy (PSP)…Arterial spin labeling perfusion MRI compensate for other diagnostic tools in evaluation of Parkinson’s disease with dementia
Objective: To test usefulness of arterial spin labeling (ASL) perfusion MRI for diagnoses of Parkinson's disease (PD) with dementia. Background: Dopamine transporter (DAT) images may…Neural mechanisms underlying step initiation failure in patients with Parkinson’s disease and freezing of gait
Objective: To investigate the neural mechanisms underlying gait initiation failure in Parkinson's disease patients with Freezing of Gait. Background: Freezing of Gait (FOG) is a…Movement related beta oscillatory activity during self-paced wrist movement in the human subthalamic nucleus
Objective: To explore voluntary movement related neuronal activity in the subthalamic nucleus in patients with Parkinson's disease (PD). Background: How the human basal ganglia processes…Increased cortical control of gait in patients with Parkinson’s disease and freezing of gait
Objective: To determine structural connectivity between the mesencephalic locomotor region (MLR) and the supplementary motor area (SMA) in freezers compared to non-freezers. Background: Freezing of…
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