Nilotinib improves motor skills, cognition and autonomic function in open-label phase I clinical trial in Parkinson’s disease with dementia and Lewy body dementia
Objective: Nilotinib, a tyrosine kinase inhibitor (TKI) was examined with the aim of showing its effect on safety comparing a lower dose of 150mg (N=6)…The NIC-PD-study –Baseline data of a randomized, placebo-controlled, double-blind, multi-centre trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson’s disease in Germany and the USA
Objective: The primary endpoint of clinical progression is measured by change in the total UPDRS score between baseline and 1) after 52 weeks of study…The application of mobile health technology to increase physical activity in persons with Parkinson’s disease
Objective: To investigate the safety, acceptability and preliminary evidence of efficacy of a mobile health (mhealth) mediated home-based exercise program to increase physical activity in…Improvement in posture, pain, and cardiac autonomic function in a prospective study of osteopathic manipulative medicine and physical therapy for camptocormia in Parkinson’s disease
Objective: A prospective cohort study of the effectiveness of osteopathic manipulative medicine (OMM) and physical therapy in improving postural control and dysautonomia in Parkinson's disease…Detailed evaluation of dyskinesias using multiple endpoints in a randomized, placebo-controlled trial of Parkinson’s disease patients with motor fluctuations
Objective: To analyze all dyskinesia data from a Phase 2b trial of fluctuating Parkinson patients in order to understand the overall impact a study drug…Stereotactic pallidotomy for Parkinson’s disease in El Salvador: One year follow up
Objective: Characterize patients with idiopathic Parkinson's disease undergoing posteroventral pallidotomy. Assess improvement in motor symptoms after pallidotomy. Background: Parkinson's disease is a neurodegenerative disease with…Minimal impact of “interleaving” on neuromodulation device battery drain when interleave frequency is halved
Objective: To contrast neurostimulator battery decay subsequent to the implementation of interleaving with that prior to interleaving. Background: Neurostimulators permit “interleaving”, which allows different same-lead…Improving parkinsonism in DBS poor-responders by surgical lead revision of subthalamic electrodes
Objective: If subthalamic deep brain stimulation (STN-DBS) results in poor symptom control or adverse side effects at low stimulation threshold surgical lead revision for optimal…A case of thalamic malignant glioma formation in a patient with STN-DBS for Parkinson’s disease
Objective: We present a case of development of malignant glioma (glioblastoma multiforme) in the area adjacent to electrostimulation zone in a patient with chronic STN-DBS,…The score changes of clinical symptom assessment scales for multiple system atrophy in 2-3 years
Objective: To examine the extent of disease progression for multiple system atrophy (MSA) during relatively long duration. Background: The knowledge of MSA natural history is…
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