Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3beta activity
Objective: To identify disease-modifying therapy for LRRK2-G2019S parkinsonism. Background: Leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of Parkinson's disease (PD) without…Effect of pharmacist-led interventions on motor symptoms and quality of life in Parkinson’s patients: A pilot study
Objective: Improvement of on-off symptoms in ambulatory patients with Parkinson's disease (PD) by introduction of a multi-faceted medication optimization program. This consisted of a patient…Effects of plantar automated mechanical stimulation (AMPS) on motor symptoms of patients with advanced Parkinson’s disease: Preliminary data of a double blind randomized clinical trial
Objective: To evaluate the effect of one session treatment with autometed mechanical peripheral stimulation (AMPS) on gait and motor functions of patients with advanced Parkinson's…Objective measures of Parkinsonian motor symptoms using a continuously worn smartwatch
Objective: To determine whether smartwatch sensor data correlates with clinician-measured Parkinson's disease symptoms. Background: Data collected with smartwatches could be used for long-term, continuous assessment…A randomized clinical trial of atomoxetine treatment for mild cognitive impairment (MCI) in Parkinson’s disease (PD)
Objective: To evaluate (1) safety and tolerability of ATM and (2) effects of ATM on attention and executive functioning in PD- MCI after 10 weeks…Applicability study of a multitask cognitive and motor exercise program for individuals with Parkinson´s disease: The COGWEB CNS Move Program
Objective: To test the applicability of a new rehabilitation program for people with Parkinson´s disease combining web-based cognitive training with motor exercises. Background: Parkinson´s disease…Effect of frequency modulation on freezing of gait in PD patients after bilateral STN DBS
Objective: To study various frequency settings and to identify the optimal frequency of bilateral subthalamic nuclei deep brain stimulation (DBS) for improvement in gait in…Comparison of four DBS lead designs under voltage and current operating modes based on patient specific simulations
Objective: To quantitatively compare the spatial extension of the electric field generated by four different lead designs operated under voltage and current modes. Background: Conventional…Implantable pulse generator (IPG) longevity decreases following each replacement surgery in Parkinson’s disease (PD) patients treated with bilateral sub-thalamic nucleus deep brain stimulation (STN-DBS)
Objective: To investigate the influence of the number of implantable pulse generator (IPG) replacement surgeries and the IPG model on battery life in bilateral STN…Suggested protocol for electroconvulsive therapy for depression in a Parkinson’s disease patient with a deep brain stimulator: A case report
Objective: To report an evidence for safety of ECT in patients with DBS in place. Background: We report a case of bilateral electroconvulsive therapy (ECT)…
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