Engrailed enhances dopamine synthesis in healthy dopaminergic neurons
Objective: The aim of the present study was to further elucidate the role of Engrailed in dopamine neurotransmission. Background: Engrailed1 and Engrailed2, collectively Engrailed, are…Computational assessment of calcium channel effects on subthalamic nucleus neuronal cells: Study of abnormal bursting patterns in Parkinson’s disease
Objective: Understanding the drug effects with respect to various ion channels on subthalamic nucleus (STN) cells is the key to safety pharmacology assessment. Here our…Effects of nilotinib on safety in open-label phase I clinical trial in Parkinson’s disease with dementia and Lewy body dementia
Objective: Nilotinib is FDA-approved for the treatment of chronic myeloid leukemia (CML) at 800mg oral dose twice daily. We examined the effects of lower doses…Levodopa-carbidopa intestinal gel in routine care of advanced Parkinson’s disease patients: Final long-term efficacy results on motor complications from the GLORIA registry
Objective: To evaluate the effect of levodopa-carbidopa intestinal gel (LCIG, designated in the United States as carbidopa-levodopa enteral suspension) on motor fluctuations and dyskinesia in…Conversion of patients from immediate release carbidopa-levodopa (IR CD-LD) and sustained release carbidopa-levodopa (SR CD-LD) to extended-release carbidopa-levodopa (ER CD-LD) in clinical practice
Objective: To evaluate the real-world response of patients who are converted from IR CD-LD and SR CD-LD to ER CD-LD in an academic practice. Background:…Taking specialist clinics into community nursing homes
Objective: Evaluate the effectiveness of delivering specialist Parkinson's care in community care home settings. Background: Our drive to improve older people's care has led to…Combined stimulation of STN and SNr for resistant freezing of gait in Parkinson’s disease (STN+SNr) – A multicenter randomized controlled trial
Objective: 54 patients with idiopathic Parkinson's disease and freezing of gait resistant to subthalamic nucleus stimulation and dopaminergic medication will be included into this German-wide…DBS targeting: Validation of 3T MR image guided targeting using post-mortem 17T MR microscopy
Objective: This work helps validate the utility of direct targeting using 3T T1 inverted sequences with atlas application during planning for DBS electrode placement. We…Efficacy of the bilateral subthalamic stimulation in Parkinson’s disease, results from the Neuromodulation Centre in Budapest
Objective: Our aim was to assess the changes in quality of life after bilateral subthalamic stimulation in our patients with Parkinson's disease and to analyze…Is the PPN a valuable target for deep brain stimulation in treatment of Parkinsonian disorders? Experience of a patient’s series
Objective: Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been reported to improve motor symptoms in idiopathic (IPS) and in atypical Parkinsonian syndromes…
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