Leveraging Large-Scale Proteomics to Identify Protein Quantitative Trait Loci and Causal Effects on Parkinson’s Disease
Objective: Integrate proteomics from the cerebrospinal fluid (CSF) and urine from the Parkinson’s Progression Markers Initiative cohort to prioritize the risk variants associated with Parkinson’s…Spastic Ataxia and Motorneuron disease as possible manifestations of ATP13A2 (PARK 9) variants
Objective: To describe 5 late-onset sporadic cases carrying either biallelic or monoallelic variants in ATP13A2, showing either spastic ataxia(Spatax) or primary lateral sclerosis (PLS) as…Understanding Patient and Care Partner Educational Preferences in Atypical Parkinsonism
Objective: To discern preferences for education and community connection among people affected by progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), or multiple system atrophy (MSA).…Effect of ADX-88178, a highly-selective mGlu4 PAM, on parkinsonism, dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Objective: To investigate the effect of the metabotropic glutamate 4 (mGlu4) positive allosteric modulator (PAM) ADX-88178 on parkinsonism, dyskinesia and psychosis-like behaviours (PLBs) in the…Anodal transcranial direct current stimulation could change the metabolomic profiles of cerebrospinal fluid in Parkinson’s disease
Objective: We tried to identify meaningful metabolite change after anodal tDCS in clinically diagnosed PD patients by adopting metabolomic analysis Background: Transcranial direct current stimulation…A network imaging biomarker of X-linked dystonia-parkinsonism
Objective: To characterize a metabolic brain network associated with X-linked dystonia-parkinsonism (XDP). Background: X-linked dystonia-parkinsonism (XDP, DYT/PARK-TAF1, Lubag) is an X-linked recessive movement disorder characterized…Correlation between levels of plasma neurofilament light chain and freezing of gait in Parkinson’s disease
Objective: This study evaluated the correlation between neurofilament light chain (NfL) and freezing of gait (FOG) in Parkinson's disease (PD). Background: PD patients frequently experience…Clinical and functional determinants of motor reserve in patients with de novo Parkinson’s disease
Objective: To determine the clinical determinants and the role of serotonergic innervation on motor reserve in patients with de novo Parkinson's disease. Background: Patients with…Timed-up-and-go tests under dual-task conditions: Influence of different tasks on gait parameters in Parkinsonian patients
Objective: To analyse the effect of dual tasking on the Parkinson gait. Background: Parkinson's disease has a strong impact on gait and posture, leading to…Clinical usefulness of tandem gait test for estimating gait and balance in de novo Parkinson’s disease
Objective: The purpose of this study is to objectively evaluate the gait and balance in patients with Parkinson’s disease showing abnormal tandem gait, using three-dimensional motion analysis.…
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