Longitudinal measurements of cerebrospinal fluid biomarkers in Parkinson’s disease
Objective: To investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, β-amyloid42, α-synuclein, neurofilament light and YKL-40 change over time and if changes correlate…Impact of prolonged temporal discrimination threshold on finger movements of Parkinson’s disease
Objective: In present study, we investigated the impact of temporal discrimination threshold (TDT) prolongation on simple repetitive finger tapping and dexterous finger movement in patients…Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies
Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…Disease severity is not predictive of the dose required for apomorphine sublingual film (APL-130277) to convert a patient with Parkinson’s disease from OFF to fully ON
Objective: Evaluate whether baseline disease severity is predictive of the effective APL-130277 dose to turn a patient with Parkinson's disease (PD) from OFF to fully…Circadian dysfunction in Parkinson’s disease: Effects on impaired gait initiation and locomotion
Objective: To investigate the impact of circadian rhythm (CR) and time of the day on the magnitude of motor impairments during gait initiation and continuation…Drug-induced parkinsonism in Taiwan
Objective: To review drug-induced parkinsonism (DIP) in Taiwan. Background: Drug-induced parkinsonism (DIP) is a frequent etiology of secondary parkinsonism. DIP must always be suspected when…Assessment of subclinical cerebellar involvement in progressive supranuclear palsy using SUIT based volumetric analysis
Objective: To explore the pattern of cerebellar atrophy if any, in patients with Progressive Supranuclear Palsy (PSP) using the SUIT (Spatially Unbiased atlas template for…Dynamic dopamine transporter images are helpful for diagnosing parkinsonism
Objective: This study is aimed at introducing a new method to get Dopamine transporter (DAT) imaging simultaneously with regional cerebral flow (CBF) imaging. Background: DAT…The role of the frontal lobe in complex walking among healthy older adults and patients with Parkinson’s disease: An fNIRS study
Objective: To investigate the role of the frontal lobe during dual tasking and obstacle negotiation, in healthy older adults and patients with Parkinson's disease (PD).…Behavioral and neuroimaging effects of LSVT-BIG and conventional physiotherapy in Parkinson’s disease
Objective: To evaluate (1) the changes of non-motor symptoms such as depression, sleep disorders, pain and cognitive deficits in PD by practicing LSVT BIG therapy…
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