Comparative score on the MDS-UPDRS scale I, II and IV in patients with Parkinson disease with and without cardiovascular risk factors.
Objective: To find any relationship between cardiovascular risk factors such as diabetes mellitus, hypertension or both and worse state in patient with PD measured with…Long-Term Motor Function and Quality of Life Outcomes from a Prospective, International DBS Registry
Objective: To report the outcomes of an ongoing prospective, international, large-scale registry of Deep Brain Stimulation (DBS) systems for Parkinson’s Disease. Background: Several studies have…Alpha-synuclein oligomers detection by proximity ligation assay in skin biopsy is a biomarker for Parkinson’s disease
Objective: To assess the presence of oligomeric alpha-synuclein (αSyn), an early pathogenic species, in skin nerve fibers of patients with Parkinson’s disease (PD) and atypical…Long-Term Safety and Efficacy of Apomorphine Sublingual Film for “OFF” Episodes in Parkinson’s Disease: Europe vs North America
Objective: Evaluate long-term safety (LTS), tolerability, and efficacy of apomorphine sublingual film (APL) for on-demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD)…Parkinson’s Disease Medication Safety in the Inpatient Cohort of a Tertiary Centre
Objective: Our study aimed to determine the accuracy of initial prescribing on hospital admission and the subsequent timing of administration of Parkinson’s disease (PD) medications…Dream enactment behavior disorder associated with pallido-nigro-luysian degeneration and tau proteinopathy
Objective: To describe the detailed clinical features and pathological findings of a patient with Pallido-nigro-luysian atrophy (PNLA). Background: PNLA is a rare neurodegenerative disorder with…Identification of a new Homozygous mutation P.R258Q In the gene SYNJ1 of an Algerian consanguine (inbred) Family suffering from early onset atypical Parkinsonism
Objective: The purpose of this observation is to demonstrate that autosomal recessive early parkinsonism is clinically and genetically heterogeneous Background: Early Onset Parkinson’s disease is…Dissociated longitudinal evolution of limbic serotonergic and striatal dopaminergic and serotonergic pathology in apathetic and non-apathetic patients in early Parkinson’s disease
Objective: To investigate the longitudinal changes in striatal and extra-striatal dopaminergic and serotonergic innervation in apathetic and non-apathetic patients during the five years after the…Motor Function Test Protocol for Parkinsonian Triad in Rodent Model of Parkinson’s Disease
Objective: To review motor deficits protocols and create a set of behavioural protocols that critically address the parkinsonian triad's quantification in Parkinson's disease models. Background:…BILATERAL SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION IN A PATIENT WITH PARKINSON DISEASE AND INTOLERANCE TO STANDARD ANTIPARKINSONIAN DRUGS – A CASE REPORT
Objective: We present a case of a 59-year-old PD patient with severe intolerance to the standard anti-Parkinsonian drugs (APDs) including levodopa (L-DOPA), MAO-B inhibitors, and…
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