Motor and cognitive symptoms in parkinsonism are associated with loss of long-range white matter fibers: Structural network changes in Vascular Parkinsonism and Parkinson’s disease
Objective: This study seeks to identify structural brain circuitry changes that may help to explain the appearance and severity of parkinsonism symptoms in clinical cohorts…Inertial-sensor based full-body kinematics reveals an unstable gait with increased variability in patients with evidence of dopaminergic denervation with 123I-FP-CIT SPECT
Objective: Distinguish patients with and without dopaminergic denervation (as assessed by 123I-FP-CIT-SPECT – DaTscan) with Inertial-sensor full body kinematics (FBK) assessment. Background: The differential diagnosis…Abnormal network interconnections dynamics correlate with levodopa-induced dyskinesia in Parkinson’s disease
Objective: To explore the pathogenesis of dyskinesia, the present study was conducted to investigate that how large-scale functional network interactions change dynamically in the temporal…Management of neuropsychiatric symptoms in Parkinson’s disease (PD) at the front door
Objective: To ascertain the number of PD patients admitted to the acute hospital with neuropsychiatric symptoms requiring a review by PD specialist, including medicine reconciliation…The role of dopamine mis-metabolism in preclinical Parkinson’s disease olfactory deficits
Objective: To gain an understanding of the underlying pathological mechanisms of Parkinson’s disease (PD)-related hyposmia using post-mortem human olfactory bulbs and an in vivo model…Depression in various forms of parkinsonism and striatal hyperkinesis
Objective: To examine of the degree of depression in various forms of Parkinsonism and striatal hyperkinesis Background: Depression is the basis of affective disorders. Almost…Temporal characterization of motor, gastrointestinal, and behavioral symptoms in a SNCA A53T transgenic mouse model of Parkinson’s disease
Objective: While multiple animal models of Parkinson’s disease (PD) have been developed with varying applicability to different aspects of the disorder, no single model effectively…Phenotype of Parkinson’s Disease in African Americans Using NIH Toolbox Motor Measures
Objective: To determine phenotypic differences using qualitative and quantitative measures between African American (AA) and white (W) patients with Parkinson’s disease (PD) at Rush University…Association between impulse control disorders and depression in drug-naïve Parkinson’s disease
Objective: To determine the association between depression and impulse control disorders (ICDs) in patients with Parkinson's disease (PD). Background: Depression is one of the most…Site investigator perspectives on exclusionary determinations of SWEDDs (Scans Without Evidence of Dopaminergic Deficit) during screening in the SURE-PD3 study
Objective: To assess investigators’ level of agreement with centrally adjudicated SWEDDs based on dopamine transporter imaging (qualitatively defined) during screening of subjects whom investigators had…
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