Neurofilament light is related to fractional anisotropy in early Parkinson’s diesease
Objective: We aimed to determine whether plasma NfL reflects changes in brain white matter integrity as measured using fractional anisotropy (FA) in patients with early…Apathy: an underestimated feature in premotor period of GBA and LRRK2 non-manifesting mutation carriers.
Objective: The aim was to detect the differences between GBA and LRRK2 mutation carriers without Parkinson’s disease and healthy controls (HC) on neuropsychiatric symptoms. Background:…Parkinson’s Disease Functional Impacts Digital Instrument (PD-FIDI): Studies Preceding Clinical Validation
Objective: Summarize the findings from 3 developmental studies of the Parkinson’s Disease Functional Impacts Digital Instrument (PD-FIDI) – a novel endpoint for assessing PD symptoms.…Determining the content of a clinician-rated tool for freezing of gait severity
Objective: This study aimed to determine clinician’s ratings of the most important triggering circumstances to be examined and aspects of freezing of gait (FOG) to…An International Pre-Implementation Survey To Assess The Acceptability Of Telemedicine As An Alternative To In-Person Clinic Consultations For PD
Objective: To assess the acceptability of virtual consultations as an option for out-patient clinic consultations for PD Background: The practice of telemedicine increased dramatically on…Single-Trajectory Multiple-Target Deep Brain Stimulation to treat Mobility and Cognition in Parkinson’s Disease: a Double-Blind, Randomized, Cross-Over Pilot Study
Objective: To assess the benefit of deep brain stimulation (DBS) to improve cognition in Parkinson’s Disease (PD). Background: Patients with advanced PD suffer from both…Limitations of conventional dopaminergic medication in advanced Parkinson’s disease: results from 127 patients treated with Levodopa Carbidopa Intestinal Gel
Objective: To evaluate the characteristics of the last conventional dopaminergic treatments in a large cohort of patients with advanced Parkinson’s Disease (APD) treated with Levodopa…MAPT mutation frontotemporal dementia with parkinsonism: when previous results can skew the diagnosis
Objective: Case report presentation. Background: In frontotemporal dementia with parkinsonism (FTDP), several mutations in MAPT gene have been identified, and numerous family cases were reported,…α-Synuclein in sympathetic nerve fibers distinguishes PRKN from LRRK2 and other genetic forms of Parkinson’s Disease
Objective: This cross-sectional observational study compared magnitudes of intra-neuronal deposition of α-synuclein in common and rare genetic forms of Parkinson’s disease. Background: Cytoplasmic inclusions of…Distinct cholinergic reactivity to dopamine is related with differed parkinsonian tremor responsiveness
Objective: We aimed at exploring the mechanisms of differed tremor responsiveness to dopamine through investigating the cholinergic and dopaminergic reactivity during dopamine administration in PD.…
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