LY-487,379 alleviates parkinsonism when administered as monotherapy in the MPTP-lesioned marmoset
Objective: To determine the effect of selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulation as monotherapy on parkinsonism, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset. Background: We…Mild parkinsonian signs in older adults correlate with an impaired functional level – a cross-sectional general population study from the “Good Aging in Skåne” cohort
Objective: We aimed to investigate the prevalence of MPS and the association with Activities of Daily Living (ADL), cognitive, physical, and autonomic function in adults…A single session of transcranial direct current stimulation improves the postural responses after external perturbations in both people with Parkinson’s disease fallers and non-fallers
Objective: To analyze the effects of a single session of transcranial direct current stimulation (tDCS) on postural responses to external perturbations in people with Parkinson's…A DIFFERENT RADIOLOGICAL PERSPECTIVE ON PARKINSON’S DISEASE AND PARKINSONISM: TRANSCRANIAL SONOGRAPHY
Objective: This study aims to investigate the reliability of Transcranial Sonography (TCS) in the diagnosis of Parkinson’s Disease (PD) and its contribution to the differential…The experience of respiratory symptoms and the impact in daily live in patients with Parkinson’s disease: a grounded theory approach
Objective: To explain what types of respiratory dysfunction people with Parkinson’s disease and atypical parkinsonism experience and how these symptoms impact their daily life. Background:…The comparisons between UPDRS and MDS-UPDRS in evaluating motor dysfunctions after subthalamic nucleus deep brain stimulation
Objective: We aimed to examine whether MDS-UPDRS are able to detect longitudinal changes in motor functions after STN-DBS in comparison to UPDRS. Background: Although MDS-UPDRS…Progression of Syndrome Specific Metabolic Brain Patterns in Patients with Various Parkinsonian Syndromes
Objective: To analyse the follow-up changes in the expression of the three syndrome specific metabolic patterns in a cohort of parkinsonian patients who underwent 18F-FDG…Apomorphine Sublingual Film for “OFF” Episodes in Parkinson’s Disease: Impact on Dyskinesia
Objective: Assess impact of apomorphine sublingual film (APL) on time spent with and functional impact of dyskinesia among patients with Parkinson’s disease (PD) and “OFF”…Effect of the mGlu2/3 orthosteric agonist LY-404,039 on abnormal involuntary movements and parkinsonism in the 6-OHDA-lesioned rat
Objective: To assess the effect of LY-404,039 on dyskinesia and parkinsonism in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease (PD). Background: LY-404,039 is an…Idiopathic rhombencephalitis involving the substantia nigra followed by rapidly progressive parkinsonian syndrome in a young patient
Objective: To describe a unique case of a healthy 21-year-old female patient diagnosed with idiopathic rhombencephalitis with predominant parkinsonian clinical signs who later developed severe…
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