The role of dopamine mis-metabolism in preclinical Parkinson’s disease olfactory deficits
Objective: To gain an understanding of the underlying pathological mechanisms of Parkinson’s disease (PD)-related hyposmia using post-mortem human olfactory bulbs and an in vivo model…Depression in various forms of parkinsonism and striatal hyperkinesis
Objective: To examine of the degree of depression in various forms of Parkinsonism and striatal hyperkinesis Background: Depression is the basis of affective disorders. Almost…Temporal characterization of motor, gastrointestinal, and behavioral symptoms in a SNCA A53T transgenic mouse model of Parkinson’s disease
Objective: While multiple animal models of Parkinson’s disease (PD) have been developed with varying applicability to different aspects of the disorder, no single model effectively…Phenotype of Parkinson’s Disease in African Americans Using NIH Toolbox Motor Measures
Objective: To determine phenotypic differences using qualitative and quantitative measures between African American (AA) and white (W) patients with Parkinson’s disease (PD) at Rush University…Association between impulse control disorders and depression in drug-naïve Parkinson’s disease
Objective: To determine the association between depression and impulse control disorders (ICDs) in patients with Parkinson's disease (PD). Background: Depression is one of the most…Site investigator perspectives on exclusionary determinations of SWEDDs (Scans Without Evidence of Dopaminergic Deficit) during screening in the SURE-PD3 study
Objective: To assess investigators’ level of agreement with centrally adjudicated SWEDDs based on dopamine transporter imaging (qualitatively defined) during screening of subjects whom investigators had…Application of PKG System for Objective Measurement and Early Identification in Parkinson’s Disease
Objective: This study aimed to assess the correlations of the PKG data with clinical scores of bradykinesia, rigidity and tremor. Background: The treatment of levodopa…Are effects of Rock Steady Boxing and PD SAFExTM on the motor symptoms of Parkinson’s disease maintained long-term? – A single-blinded randomized controlled trial
Objective: To determine if the benefits associated with RSB and PD SAFExTM on the motor symptoms of PD wash out over time. Background: Parkinson’s disease…Postmenopausal hormone therapy and Alzheimer’s disease, dementia, and Parkinson’s disease: A systematic review and time-response meta-analysis
Objective: The study aim was to determine the relation between menopausal hormone therapy and Alzheimer's disease, dementia, and Parkinson's disease in human subjects. Background: We…Efficacy and security starting safinamide treatment with 100 mg/day in Parkinson’s disease
Objective: Evaluating the efficacy and security starting safinamide treatment with 100 mg/day in PD Background: Safinamide has a unique dopaminergic and non-dopaminergic mode of action…
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