LRRK2 p.G2019S and p.N2081D variants as modifiers of glucocerebrosidase activity
Objective: To examine whether the activity of the lysosomal enzyme glucocerebrosidase (GCase) is associated with LRRK2 variants. Background: Mutations in GBA (which encodes GCase) and…Loss of CHCHD2 and CHCHD10 disrupts mitochondrial cristae phenocopying patient mutations
Objective: Characterization of novel of a novel CHCHD2 (C2) and CHCHD10 (C10) knockout mouse model. Background: Dominant mutations in the mitochondrial paralogs CHCHD2 (C2) and…Sex differences on dynamic functional connectivity in Parkinson’s disease and healthy controls
Objective: The main objective was to evaluate the influence of sex in time-varying functional connectivity (FC) characteristics in Parkinson’s disease (PD) patients and healthy adults…Temporal properties of resting-state functional MRI are associated with ON/OFF levodopa MDS-UPDRS III scores in patients with Parkinson’s disease
Objective: To explore the relationship between temporal resting-state functional magnetic resonance imaging (fMRI) properties and ON/OFF Levodopa motor performance scores in patients with Parkinson's disease…Brain cholinergic dysfunction in patients with isolated REM sleep behavior disorder: A clinical and 11C-Donepezil PET follow-up study
Objective: In this follow-up study, we aimed to explore the temporal changes in brain acetylcholinesterase activity and cognitive function of iRBD patients. Background: Isolated REM…Time Series Analysis Applied to EEG Shows Increased Global Connectivity During Motor Activation in PD Patients Compared to Controls
Objective: To apply time series analysis techniques to EEG studies to study connectivity changes during motor activation in a cohort of Parkinson´s disease subjects (PD)…Quantitative Autonomic Testing in Parkinson’s Disease
Objective: This study was done to find the clinical correlates with quantitative autonomic testing in Parkinson's disease. Background: Autonomic dysfunction is common and causes variety…Pet ownership associated with lower apathy and motor severity in female participants with PD
Objective: This study evaluated the impact of pet ownership on Parkinson’s disease (PD) severity and related symptoms. Background: PD is a common neurodegenerative disease characterized…Apomorphine improves pulmonary function in parkinsonian patients
Objective: Aim of the study; to investigate if apomorphine might facilitate weaning from mechanical ventilation in parkinsonian patients. Background: Apomorphine is an effective treatment for PD…The interaction of Parkin and TAF15 for the Drosophila in which neuronal defect was induced
Objective: Our study proposes a novel regulator for the protection of TAF15-induced proteinopathy and adds to our understanding of the exact pathogenic mechanism for TAF15-induced…
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