Dopaminergic and Synaptic Alterations in SWEDD: Insights from [¹⁸F] FE-PE2I and [¹¹C] UCB-J PET Imaging
Objective: To investigate dopaminergic and synaptic density in SWEDD patients compared to idiopathic Parkinson’s disease (IPD) and healthy controls (HCs). Background: Scans Without Evidence of…Evaluation of swallow tail sign on 1.5 Tesla Magnetic Resonance Imaging in Parkinson´s disease patients in a tertiary hospital
Objective: To evaluate the swallow tail sign in 1.5 Tesla magnetic resonance imaging (MRI) scans of patients diagnosed with Parkinson's disease (PD). Background: Nigrosome-1 appears…Mining Metabolomics GWAS for Key Parkinson’s Disease Variants: A Bioinformatics Approach to Genetic-Metabolic Associations
Objective: To propose a novel approach to explore genetic-metabolic interactions in Parkinson’s disease (PD) by integrating the largest genome-wide association studies (GWASs) for PD and…Inflammatory profile in LRRK2-associated prodromal and clinical PD:a cross-sectional study
Objective: To investigate the peripheral inflammatory cytokine levels and their associations with clinical severity, dopaminergic presynaptic degeneration in asymptomatic carriers and PD patients with LRRK2 mutation.To investigate…VPS35-Related Parkinson Disease in a Patient of Korean Ancestry: A Case Report
Objective: To report a case of a 65-year-old Korean woman diagnosed with a rare gene mutation involving VPS35 linked to Parkinson’s disease (PD). Background: Major…Utilizing the Global Parkinson’s Genetics Program (GP2) to develop a precision medicine recruitment protocol
Objective: Can the Global Parkinson’s Genetics Program (GP2, http://gp2.org/) leverage its rich data and connectivity to address the growing issue of identifying individuals that can…Association of sequence alterations in the promoter region of the RAB7L1 gene with lysosomal hydrolase activity in blood and reduced risk of Parkinson disease
Objective: The aim of this case-control study was to examine the association between SNPs located in the promoter region of the RAB7L1 gene and Parkinson's…Subthalamic Nucleus Stimulation May Suppress Both Ipsilateral and Contralateral Local-Field-Potential Magnitude
Objective: Determine whether ipsilateral subthalamic nucleus (STN) stimulation affects local field potential (LFP) power in the contralateral STN to inform clinical decision making. Background: A…Initial Experience with a Crossover Study Comparing Automated Connectomic Programming to Standard Clinical Programming for DBS
Objective: To compare the efficacy of a novel automated connectomic programming (ACP) algorithm to standard clinical programming (SCP) in patients undergoing deep brain stimulation (DBS)…A Retrospective, Multicenter, Harmonized Data Collection for Uncovering DBS Long-Term Axial Response
Objective: To determine pre-surgery (e.g., motor phenotype), during-surgery (e.g., electrodes' position), and post-surgery (e.g., stimulation parameters) factors predicting DBS-induced effects on axial symptoms in people…
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