Access to rehabilitation therapy for people with Parkinson’s disease in Rome, Italy
Objective: This survey aimed to evaluate patients’ awareness of healthcare roles, access to care, and use of rehabilitation services in the Rome region, Italy. Background:…Systemic antioxidant response to bilateral anodal transcranial direct current stimulation in Parkinson’s disease: findings from a pilot randomized controlled study
Objective: To investigate whether repeated sessions of bilateral anodal tDCS can influence circulating antioxidant enzyme levels and fatigue severity in individuals with Parkinson’s disease. Background:…Head Trauma History and Motor Phenotype in Early Parkinson’s Disease
Objective: To examine whether patients with Parkinson's disease (PD) and a history of head trauma (HT) differ from those without HT in terms of motor…Challenging Traditional Paradigm: Clinical Outcomes of Early vs Late Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Objective: Deep brain stimulation(DBS) of subthalamic nucleus(STN) is an established treatment for Parkinson’s disease(PD). DBS has been reserved for patients with long-standing disease and disabling…Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1-associated Parkinson’s Disease
Objective: This study focuses on the timing of DBS in relation to PD onset and explores cognitive trajectories across different GBA1 variant classes, with a…SNCA-Targeting RNAi Therapeutics Prevent Disease Progression in a Synucleinopathy Mouse Model and Enable Robust, Prolonged, and Safe Alpha-Synuclein Protein Reduction in the Cynomolgus Monkey Central Nervous System
Objective: Assess the nonclinical efficacy and safety of C16-conjugated siRNAs targeting SNCA mRNA (SNCA siRNA). Background: Parkinson’s disease is a neurodegenerative disorder with an estimated…Investigating Subthalamic Neuronal Activity in Parkinsonian Patients with Hemidystonia
Objective: In this study we aimed to investigate differences in the subthalamic nucleus (STN) activity in Parkinson’s disease (PD) patients who developed hemidystonia. Background: STN…Recruitment Strategies in a Diverse Parkinson’s Disease Cohort: Lessons from the East London Parkinson’s Disease Project
Objective: To describe and evaluate recruitment strategies implemented in the East London Parkinson’s Disease (ELPD) Project that were designed to enhance engagement and participation among diverse communities in…EAGLE: Protocol for a Phase 3 Study to Evaluate the Efficacy and Safety of Two Mobile Applications Combined with Immediate-Release CD/LD for the Management of Idiopathic Parkinson’s Disease
Objective: To evaluate the efficacy and safety of Hybridopa A and Hybridopa B, combination products of immediate-release carbidopa/levodopa (IR CD/LD) and therapeutic mobile applications, in adults with idiopathic Parkinson’s disease (PD) on a…Levodopa dosing regimen influences repetitive tongue force maintenance in Parkinson’s disease
Objective: To investigate whether levodopa (LD) dosing regimen influences the dynamics of repetitive maximal tongue pressure (MTP) in patients with Parkinson’s disease (PD). Background: Reduced…
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