Proof-of-concept clinical trial: Prevent cognitive decline in GBA-associated Parkinson’s Disease
Objective: To prevent cognitive decline in GBA-associated Parkinson’s Disease (PD). Background: Dementia represents a key milestone in the course of PD with limited effective treatments…The Synuclein-One Study: Detection of Cutaneous Phosphorylated alpha-synuclein for the Diagnosis of the Synucleinopathies
Objective: The Synuclein-One study is an NIH-funded 30-site, multicenter trial of 428 patients with synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple…Association between changes in hippocampal volumes, cognition, and CSF markers in Parkinson’s Disease
Objective: To assess whether changes in hippocampal subfield volumes are associated with cognition or CSF β-amyloid 1–42 (Aβ42) levels in Parkinson’s Disease (PD). Background: Hippocampal…Visuo-spatial processing is linked to cortical glutamate dynamics in Parkinson’s disease – a 7 Tesla functional MRS study
Objective: To investigate alterations of glutamate metabolism in the occipital cortex during visual processing in patients with Parkinson’s disease (PD). Background: Cognitive decline is a…Management of constipation in Parkinson’s patients presenting with acute sigmoid volvulus to Royal Berkshire Hospital,Reading, UK
Objective: To evaluate management of constipation in acute sigmoid volvulus in Parkinson’s. Background: Constipation is one of the main and disabling non motor symptoms in…Plasma glucosylsphingosine in GBA1 E326K, N370S and L444P mutation carriers with and without Parkinson’s disease
Objective: To measure plasma glucosylsphingosine levels in heterozygous carriers with and without Parkinson's disease (PD) of three variants in GBA1: 1. E326K (risk factor for…Living with Parkinson’s disease scale: First validation study among English-speaking population
Objective: To analyse the psychometric properties of the English version of the Living with long term conditions (LwLTCs) scale in people living with Parkinson’s disease…Intrarater and interrater reliability of the 3 meter backward walk test in individuals with Parkinson disease.
Objective: Determine the intrarater and interrater reliability of the three meter backward walk (3 MBW) test for individuals diagnosed with Parkinson Disease. Background: Background- Parkinson…Stability and predictability of motor symptom control in patients with advanced Parkinson’s disease (aPD) receiving continuous subcutaneous foslevodopa/foscarbidopa (LDP/CDP)
Objective: To evaluate temporal changes in motor states (OFF and ON without troublesome dyskinesia [TD; good ON]) throughout the waking day in patients with aPD…Case report on the use of a High Frequency Vibrotactile Stimulation and Cueing Device over 4 months in a patient with Parkinson’s Disease and refractory symptoms
Objective: To document motor symptoms of a patient with PD whilst using a Focussed Vibrotactile Stimulation and Cueing Device (FVCD). Background: A 77-year-old patient with…
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