Evaluating Inter-rater Variability in UPDRS Using IMU: A Comparison Between Beginner and Experienced Specialists
Objective: This study aims to determine whether an inertial measurement unit (IMU) can detect differences in the consistency of Movement Disorder Society-Unified Parkinson's Disease Rating…Incidence and Associated Factors for Phenoconversion of Parkinson’s Disease in the Chinese Community Older Adults with LRRK2 G2385R and R1628P Variants
Objective: To investigate the 10-year accumulated incidence and associated factors for phenoconversion of Parkinson’s disease (PD) in community older adults carrying LRRK2 G2385R or/and R1628P variants. Background: Previous…The Cleveland Clinic-Virtual Home Environment (CC-VHE): A Reliable Way to Trigger Freezing of Gait in Parkinson’s disease
Objective: To describe the development, safety, and efficacy of the Cleveland Clinic-Virtual Home Environment (CC-VHE) in provoking freezing of gait (FOG) in Parkinson’s disease (PD).…A personalized gait signature assay in Parkinson’s disease
Objective: To establish a personalized gait signature assay to inform on progression, phenotype and effects of intervention of gait abnormalities in PD. Background: Gait signatures…Health Disparity in Rural Southern California
Objective: To analyze the demographic and clinical characteristics of hispanic patients with Parkinson's disease in rural southern California Background: Parkinson’s disease (PD) is the second…The Role of Knowledgeable Informants in the Early Detection of Parkinson’s Disease
Objective: To investigate the reporting of changes observed by Knowledgeable Informants (KIs) and people with Parkinson’s disease (PwPD) prior to a Parkinson’s disease (PD) diagnosis.…Parkinson’s Disease: Increased Presence of Neuropsychiatric Symptoms and Non-Motor Issues Drive Higher Medication Use and Costs
Objective: To compare neuropsychiatric disorders (NPsy), other non-motor symptoms (NMS), and associated medication use and costs in individuals with advanced Parkinson’s Disease (aPD) with those…The influence of Caffeine intake on Type 2 Diabetes Mellitus mediated risk of Parkinson’s Disease.
Objective: The objectives are to investigate if a diagnosis of Type 2 Diabetes Mellitus (T2DM) is associated with increased risk of developing Parkinson's Disease (PD)…Deferiprone improves striatal dopamine by reducing neuroinflammation and oxidative stress in MPTP-induced mice model of Parkinson’s disease
Objective: This study aimed to investigate the effect of deferiprone on the striatal DA, oxidative stress and neuroinflammation markers as well as motor deficits in…Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy
Objective: In the present study, we aim to counteract regulatory and transcriptional modifiers of autophagy to enhance neuroprotective proteostasis and rescue alpha-synuclein (asyn) toxicity in…
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