The role of serotonergic mechanisms in the formation of levodopa-induced drug-induced dyskinesias in Parkinson’s disease
Objective: To study the quantitative content of serotonin and dopamine in the blood plasma of patients with Parkinson's disease and to conduct a clinical and…Alterations in gut microbiota composition in VPS35 associated PARK17 mouse model
Objective: This study explores whether host genetics such as specific VPS35 genetic variations linked to PD can shape the gut microbiome. Background: Heterozygous (D620N) mutation…Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression
Objective: To characterize the Dnajc13 p.N860S mouse model of familial Parkinson’s disease Background: DNAJC13/RME-8 is a large, multi-domain molecular co-chaperone that facilitates membrane recycling and…Parkinson’s disease motor phenotypes delineated by pallidal and subthalamic neurophysiology and machine learning
Objective: The objective of this study was to develop a machine learning (ML) algorithm capable of predicting motor phenotypes in Parkinson's disease (PD) using intraoperative…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…Investigating the Role of Age and Neurological Status on Adaptive Balance Strategies: A Systematic Review Utilizing Big Data Techniques
Objective: To examine the influence of age and neurological status on adaptive balance strategies using big data analytics and systematic review methodologies. Background: Balance control…White Matter Abnormalities in Progressive Supranuclear Palsy (PSP) vs. Parkinson’s Disease (PD): Evaluation with a Convolutional Neural Network (CNN)-Based Tool
Objective: This study aimed to compare white matter hyperintensity (WMH) burden between PSP and PD using a novel AI-based tool for more accurate WMH volume…International Mentorship in PPMI Clinical Translation (IMPaCT): Engagement Initiatives for Clinical Participants in the United States (US)
Objective: Describe cohort engagement strategies conducted by PPMI IMPaCT Program among US participants. Background: Retention in longitudinal studies is vital for study for data integrity/analysis.1…Unraveling Functional Overlay in Parkinson’s Disease: A Diagnostic Challenge
Objective: To highlight the diagnostic complexities of functional movement disorders (FMD) in Parkinson’s disease (PD) and the role of neurophysiological studies in differentiating functional overlay…A Scoping Review of Psychological Interventions across domains to improve Quality of Life in Persons with Parkinson’s Disease
Objective: This scoping review examines the evidence for psychological interventions across the domains of therapy, activity, tele-health and integrated care for improving Quality of Life…
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