Neuroprotective Action of Exogenous Melatonin in Parkinson Disease Patients and its Impact on Daily Routine: a Systematic Review
Objective: This study aims to evaluate the neuroprotective action of exogenous melatonin in Parkinson disease patients and its impact on daily routine. Background: Parkinson Disease…The “Cat Killer’s Disease”: Lived Experience of Parkinson’s disease Patients in Ethiopia
Objective: The main objective of this study is to explore the lived experience of PD patients in Addis Ababa, Ethiopia. Background: Parkinson's disease (PD) is…Boosting Parkinson’s Disease Diagnosis: How Training Ethiopian Healthcare Workers and Enhancing Community Level Awareness Led to a Surge in Case Identification
Objective: The study assessed the effectiveness of a capacity development training program in improving the diagnosis of Parkinson's Disease (PD) by healthcare professionals Background: Parkinson's…Device-aided Recording of Gait Parameters and Motor Fluctuations in Patients with advanced Parkinson’s disease in the Home Environment
Objective: To objectively assess mobility and gait parameters in the ON and OFF state in patients with advanced Parkinson's disease (PD) under everyday conditions using…Experience of the LARGE-PD protocol in a health center in Buenos Aires, Argentina
Objective: Disseminate and inform the activity of the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD) in Argentina. Background: The LARGE-PD consortium…The epigenetic association of Parkinson’s disease risk gene- GPNMB rs199347 with drinking
Objective: This paper examines the epigenetic association of rs199347 polymorphism variants of the GPNMB with drinking and DNA methylation changes. Background: Neuroinflammatory response induced by alcohol…Does hyposmia induce apathy in early Parkinson’s disease? Lessons from structural brain connectivity
Objective: To study changes in microstructural integrity of white matter tracts associated with apathy in patients with early Parkinson’s disease (PD) and hyposmia Background: Smells…LRRK2 kinase activity regulates sphingolipid hydrolase enzymatic activities in different cell lines: induced pluripotent stem cell-derived dopaminergic neurons, primary monocyte‐derived macrophages and SH-SY5Y
Objective: To assess whether inhibition of the kinase activity of LRRK2 affects changes in enzyme activity of sphingolipid hydrolase in the culture of dopaminergic neurons…Use of concomitant medications before and after treatment with levodopa/carbidopa intestinal gel in patients with advanced Parkinson’s disease: summary of phase 3 and real-world studies
Objective: Evaluate the use of concomitant Parkinson’s disease (PD) medications before and after treatment with levodopa/carbidopa intestinal gel (LCIG) using data from phase 3 clinical…Hypoxia‑induced astrocyte activation and its protective effect on Parkinson’s disease
Objective: In this study, we aimed to investigate whether hypoxic conditions can activate cerebral astrocytes and explore their protective effects on α-synuclein pre-formed fibril (PFF)-treated…
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