Sex-specific genetic architecture of autosomal risk for Parkinson’s Disease: from the Global Parkinson’s Genetics Program
Objective: To investigate potential differences in autosomal risk factors between males and females with Parkinson’s Disease (PD). This analysis was performed within and across genetically…Returning Secondary Health Findings in the PD GENEration study
Objective: To provide secondary health findings (SHF) results to participants enrolled in the PD GENEration study via CLIA genetic testing using whole genome sequencing (WGS)…Identifying Differential DNA Methylation Pathways in Parkinson’s Disease and REM Sleep Behavior Disorder
Objective: To investigate differential methylation patterns of cell-free DNA (cfDNA) between Parkinson’s Disease (PD), REM Sleep Behavior Disorder (RBD), and Healthy Control (HC) groups. Background:…Studying the Influence of Genetic Variations on Functional Performance in Parkinson’s Disease
Objective: To evaluate whether individuals with one of the seven most common genetic variants associated with Parkinson’s Disease (PD) exhibit differences in physical function performance…Revealing Novel Genetic Contributors to Parkinson’s Disease in a Chinese Cohort: An Elaborate Examination within the CPD10KGP
Objective: This study employs next-generation sequencing (NGS) and long-read sequencing data (LRS) in Chinese AR-PD families to uncover novel genes, enhancing our genetic comprehension of PD. Background:…Management of peri-lead cyst after Deep Brain Stimulation surgery: Review of literature and an illustrative case report
Objective: Identification and management of an unusual complication following Deep Brain Stimulation surgery (DBS). Background: DBS is a well established treatment modality that has found…Low Frequency Directional Deep Brain Stimulation of the Cuneiform Nucleus for Levodopa-Resistant Freezing of Gait: Six-Month Outcomes.
Objective: This is a prospective, open-label, single-arm study to assess safety and efficacy of cuneiform(CnF) deep brain stimulation(DBS) in Parkinson's disease(PD) patients with levodopa-refractory freezing…Intraoperative deep brain stimulation intrinsic lead migration
Objective: To characterize the intrinsic deep brain stimulation (DBS) lead migration as it relates to different deep brain targets. Background: Effective DBS relies on careful…Distinguishing DBS and Non-DBS Parkinson’s Patients Using Recurrence Plots and Vision Transformers
Objective: To introduce an innovative method for distinguishing gait patterns in Parkinson’s Disease (PD) patients with medical or surgical treatment and healthy controls, by exploiting…Prodromal Clinical Markers of Parkinson disease in patients with Gaucher disease and their parents
Objective: To determine the presence of prodromal markers of Parkinson’s disease (PD) in Gaucher disease (GD) patients and their parents. Background: GBA gene mutation is…
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