Assessing The Role Of Afg3l2 Pathogenic Variants In Parkinson’s Disease
Objective: The aim of this study is to investigate the potential link between AFG3L2 rare pathogenic/likely pathogenic variants with Parkinson’s disease (PD). Background: AFG3L2 is…Deciphering the NLRP3-Driven Olfactory–Brain Axis in Parkinson’s disease: Neuroprotective Role of Betulin
Objective: The present study aimed to elucidate the molecular mechanism underlying bidirectional olfactory–brain dysfunction mediated through NLRP3 inflammasome activation in cellular models of PD and…App-Based Speech Assessment Differentiates PD and PSP: A Feasibility Study in Italian Speakers
Objective: To evaluate the feasibility of app-based speech assessment in Parkinson’s disease (PD) and progressive supranuclear palsy (PSP), and to explore group differences in speech…Sublingual Apomorphine Tolerability in Clinical Practice: 18-months Post launch experience in Europe
Objective: Describe the post-marketing safety profile of Sublingual apomorphine (SL-APO) in Europe during the first 18 months after launch. Background: SL-APO is an on-demand therapy…Comparability of Smartphone App and Booth Recordings for Robust Acoustic Speech Monitoring in Parkinson’s Disease
Objective: To assess the technical equivalence and scalability of remote app-based recordings against gold-standard laboratory conditions to identify reliable speech features suitable for longitudinal monitoring…Effectiveness of Switching from Levodopa-Carbidopa Intestinal Gel to Levodopa-Carbidopa-Entacapone Intestinal Gel in Patients with Refractory Biphasic and Peak-of-Dose Dyskinesia
Objective: To evaluate the clinical benefit on motor complications of transitioning from levodopa-carbidopa intestinal gel (LCIG) to levodopa-carbidopa-entacapone intestinal gel (LECIG) in a cohort of…DBS withdrawal syndrome in Parkinson’s disease: Clinical features and outcomes of two new cases
Objective: To report two cases of deep brain stimulation (DBS) withdrawal syndrome in Parkinson’s disease (PD), including one without typical risk factors. Background: DBS withdrawal…Subthalamic Deep Brain Stimulation Produces Consistent Improvements in Sleep Quality and Daytime Sleepiness in Parkinson’s Disease: A Systematic Review and Meta-analysis
Objective: This study aims to determine the effects of subthalamic nucleus deep brain stimulation (STN‑DBS) on sleep quality and daytime sleepiness in Parkinson’s disease (PD).…Deep brain stimulation improves levodopa-induced dyskinesias beyond medication reduction in Parkinson’s disease
Objective: To determine whether the improvement in levodopa-induced dyskinesias after deep brain stimulation is primarily associated with reduction in dopaminergic medication or with a direct…Can Prayer Beads Quantify Bradykinesia? An Ultra-Low-Cost Approach to Motor Assessment in Parkinson’s Disease
Objective: To explore the potential use of portable mechanical counters as a simple approach to quantifying finger movement activity in the evaluation of bradykinesia. Background:…
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