Understanding patient perceptions of advanced Parkinson’s disease (aPD) treatments
Objective: To explore patients’ perceptions of treatment options for aPD and treatment decision considerations. Background: As PD advances, some people with Parkinson’s (PwP) on oral…Vaccination from Covid-19 in people with Parkinson`s disease
Objective: To assess safety and efficacy of COVID-19 vaccines against SARS-CoV-2 in people with Parkinson’s disease. Background: Different forms of vaccines have been developed to…The Parkinson’s Disease Composite of Executive-Functioning (PaCEF): A measure for detecting cognitive decline for Parkinson’s disease clinical trials
Objective: To develop a cognitive composite measure that is sensitive to decline in executive functioning for use in Parkinson’s disease (PD) clinical trials. Background: The…Cardio-respiratory fitness is associated with corticospinal excitability and motor learning in Parkinson’s Disease.
Objective: To explore associations between cardio-respiratory fitness (VO2peak), cortico-spinal excitability (CSE) and motor learning in people with Parkinson's Disease (PwPD). Background: PwPD show alterations in…Video-Based Motor Function Assessment by Professional Raters or by Software in Patients with Parkinson’s Disease
Objective: To evaluate the consistency of objective movement variables between a computer vision-based movement dysfunction assessment software (MoDAS) and professional raters in video-based motor function…Amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): feasibility in the human
Objective: To assess the feasibility of continuously amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson's disease (PD) patients using a bidirectional, closed-loop brain…A Parkinson Shoe with Combined Plantar Pressure and Vibratory Stimulation in Parkinson’s Disease Patients with Freezing of Gait: A Randomized Controlled Trial with Plantar Pressure Analysis
Objective: To explore the effect of PD shoes on plantar pressure in PD patients with FOG. Background: Dysfunction of peripheral sensory systems, including decreased cutaneous mechanoreceptors…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Association Between Antiepileptic Drugs and Subsequent Parkinson’s Disease in East London
Objective: To investigate the association between antiepileptic drugs (AEDs) prescription and subsequent Parkinson’s disease (PD). Background: Recent observational studies have highlighted an association between epilepsy…Diagnostic accuracy of susceptibility map-weighted MRI for discriminating tremor-dominant Parkinson’s disease and essential tremor
Objective: We investigated the diagnostic accuracy of nigrosome using susceptibility map-weighted imaging (SMwI) in distinguishing tremor-dominant Parkinson's disease (PD) and essential tremor (ET). Background: Tremor is…
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