Association of sequence alterations in the promoter region of the RAB7L1 gene with lysosomal hydrolase activity in blood and reduced risk of Parkinson disease
Objective: The aim of this case-control study was to examine the association between SNPs located in the promoter region of the RAB7L1 gene and Parkinson's…Subthalamic Nucleus Stimulation May Suppress Both Ipsilateral and Contralateral Local-Field-Potential Magnitude
Objective: Determine whether ipsilateral subthalamic nucleus (STN) stimulation affects local field potential (LFP) power in the contralateral STN to inform clinical decision making. Background: A…Initial Experience with a Crossover Study Comparing Automated Connectomic Programming to Standard Clinical Programming for DBS
Objective: To compare the efficacy of a novel automated connectomic programming (ACP) algorithm to standard clinical programming (SCP) in patients undergoing deep brain stimulation (DBS)…A Retrospective, Multicenter, Harmonized Data Collection for Uncovering DBS Long-Term Axial Response
Objective: To determine pre-surgery (e.g., motor phenotype), during-surgery (e.g., electrodes' position), and post-surgery (e.g., stimulation parameters) factors predicting DBS-induced effects on axial symptoms in people…From Campotomy to MR-Guided Focused Ultrasound Pallidothalamic Tractotomy for Parkinson’s: A Systematic Review in the Context of a Phase III Study
Objective: To summarize and review efficacy and safety evidence of pallidothalamic tractotomy (PTT) using MR-guided focused ultrasound (MRgFUS). Background: Speigel and Wycis performed lesions in…Weight loss post deep brain stimulation to bilateral subthalamic nuclei in a Parkinson’s disease with PARKIN mutation – A Harbinger sign of malignancy
Objective: We present a challenging case of genetic PD who presented with progressive weight loss and constipation despite post-DBS and was found to have malignancy.…Application of Respiratory-Controlled Cardiopulmonary Coupling in Early Diagnosis of Parkinson’s Disease
Objective: Studies have shown that autonomic nervous symptoms precede motor symptoms in PD, making autonomic function assessment a potential tool for early PD diagnosis. This…Exploring the Trade-offs Between Speech and Gait in Parkinson’s Disease
Objective: The goal of the study was to explore speech and gait performance trade-off when individuals with Parkinson’s disease (PD) engaged in concurrent speaking and…Parkinson’s Disease (PD) and Type II Diabetes (T2DM): Risk and Progression
Objective: To test whether PD risk is greater in those with a prior diagnosis of T2DM, and whether T2DM is associated with faster PD clinical…Metabolic network signature of quantitative motor effects following deep brain stimulation in Parkinson’s disease
Objective: To integrate [18F]-FDG PET (fPET) and objective motor performance to unravel metabolic networks associated with deep brain stimulation (DBS) outcomes in Parkinson’s disease (PD).…
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