Evaluation of the effect of adding a mGlu2/3 orthosteric antagonist to a highly selective 5-HT2A antagonist on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Objective: To determine whether the therapeutic effect of serotonin 2A (5-HT2A) receptor antagonism on dyskinesia and psychosis may be reversed by orthosteric antagonism of metabotropic…Subcutaneous Foslevodopa/Foscarbidopa in Patients With Advanced Parkinson’s Disease: Results From a Randomized, Double-blind, Double-dummy Phase 3 Trial
Objective: To evaluate the efficacy and safety/tolerability of 24-hour/day continuous subcutaneous infusion (CSCI) of foslevodopa/foscarbidopa (a soluble formulation of levodopa/carbidopa prodrugs) vs oral levodopa/carbidopa in…Abnormal streamline density of the tremor network in tremor dominant Parkinson’s disease and Essential tremor plus syndrome
Objective: To evaluate streamline density (SD) of the basal ganglia-thalamocortical (BGTC) and cerebello-thalamocortical (CTC) network in tremor dominant Parkinson’s disease (TDPD) and essential tremor plus…Capturing the complexity of patients with parkinsonism: Baseline characteristics of participants in the PRIME-UK cross-sectional study
Objective: This cross-sectional study seeks to describe the symptomatology and health needs of a representative sample of people with parkinsonism, including those living with frailty,…Frequency of depression and predictors of mood change among caregivers of Parkinson’s disease patients
Objective: The aim of the present study was to analyze the frequency of depression in a cohort of caregivers of patients with Parkinson ́s disease…Developing infrastructure for a multi-arm multi-stage trial in Parkinson’s
Objective: To scope and develop infrastructure for the first multi-arm multi-stage (MAMS) platform trial for Parkinson’s disease, the Edmond J Safra ACT-PD initiative (EJS ACT-PD).…The key is “any movement”: results from a Cochrane systematic review and network meta-analysis on physical interventions for Parkinson´s disease
Objective: To compare the efficacy and safety of physical interventions for people with Parkinson's disease (PD). Background: Physical interventions are effective in managing PD, but…Parkinson disease with LRRK2 mutation associated with upper motor neuron dysfunction
Objective: We report a patient with genetic Parkinson disease associated with upper motor neuron dysfunction. Background: Leucine-rich repeat kinase 2 (LRRK2) mutations have been extensively…Correlation between clinical scales and gait in Parkinson’s disease
Objective: The objective of this study is to verify the correlations between cognitive and motor clinical scales and gait in individuals with PD and whether…The changes in activities of daily livings after deep brain stimulation in Parkinson’s disease
Objective: We aimed to clarify long-term changes in activities of daily living in patients with Parkinson's disease (PD) who underwent deep brain stimulation (DBS). Background:…
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