Monogenic Portal of the Global Parkinson’s Genetics Program (GP2)
Objective: To support the efforts of the Global Parkinson’s Genetics Program (GP2, http://gp2.org/) Monogenic Hub, by developing an easy-to-use online platform for case/family submission. Background:…Homozygous PRKN exon 3 deletion in an early-onset Parkinson’s disease family from the Kadazan-Dusun ethnic group indigenous to Sabah, Malaysia
Objective: To determine the causal gene for early-onset Parkinson’s disease (PD) in a Malaysian family of Kadazan-Dusun ethnicity. Background: Among Asian populations, relatively little is…CHARACTERIZATION OF LRP10 EXPRESSION IN LEWY BODY DISORDERS AND IPSC-DERIVED BRAIN CELLS
Objective: Our objective is to characterize endogenous low-density lipoprotein-related protein 10 (LRP10) expression in human induced pluripotent stem cell (iPSC)-derived brain cell types, post-mortem brain…RNA Editing in Parkinson’s Disease Shows Changes in Mitochondrial and Manganese-Binding Pathways in Multiple Brain Regions
Objective: To identify RNA editing alterations associated with Parkinson’s disease (PD) in the Dorsal Motor Nucleus of the Vagus (DMV), Substantia Nigra (SN), and Cingulate…An Eyes-Open/Closed Manipulation Reveals Disrupted Default Mode Network Connectivity in Parkinson’s Disease and REM Sleep Behavior Disorder
Objective: To spatially localize disruptions in default mode network connectivity in prodromal and diagnosed Parkinson’s disease relative to controls. Background: Previously our research team reported…Feasibility study of diffusion tensor imaging fiber tracking in PD patients after DBS operation
Objective: To explore the feasible of depicting the nigrostriatal pathway (NSP), dentate rubro thalamic (DRTT) and hyperdirect pathway (HDP) for the postoperative PD patients with…The Influence of Affective Priming on the Speech Production Network in Parkinson’s Disease
Objective: Examine Parkinson’s disease (PD) related changes in the speech production network (SPN) and its reaction to emotional distraction. Background: PD can cause speech alterations…Longitudinal Study of Grey Matter Nuclei in Early Parkinson’s Disease using Diffusion Kurtosis Imaging
Objective: We aimed to determine whether microstructural characteristics of key grey matter nuclei would be differentially altered between baseline and two-year timepoints in Parkinson’s disease…Beta synchronization of the subthalamic nucleus during self-initiated and externally generated movement in parkinsonian patients in OFF and ON states
Objective: The aim of this study is to estimate the level of beta synchronization of the subthalamic nucleus (STN) evoked by internally and externally generated…Striatal dopamine transporter imaging in Parkinson’s disease drug-naïve patients: focus on sexual dysfunction
Objective: To evaluate whether the 123I-FP-CIT striatal uptake differs in Parkinson’s disease (PD) drug-naïve patients with and without sexual dysfunction. Background: Sexual dysfunction is one…
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