Lysosomal Lipid Dysregulation in Parkinson’s Disease: Genetic and Medication Effects in CSF Metabolomics
Objective: Define lipid signatures in sporadic, LRRK2, and GBA1 PD and pre-manifest carriers and assess medication impacts. Background: Lysosomal dysfunction contributes to PD, particularly in…Privacy and Personalisation: Predicting Parkinson’s Severity with Federated Learning
Objective: To improve privacy and personalisation for artificial intelligence (AI), this work compared federated learning (FL) to a conventional, centralised system for predicting Movement Disorder…Facial Blendshape Index(FBI) for Quantification of Hypomimia on Parkinson´s Disease
Objective: To evaluate the validity of ExpressionTracker, an app generating personalized facial blendshapes, for objective quantification of hypomimia in patients with Parkinson’s disease (PD) [1].…Chronic DBS Stimulation’s effects after 1-hour off stimulation
Objective: This study investigates the changes in local field potential (LFP) activity during chronic deep brain stimulation (DBS) in patients with Parkinson's disease (PD) during…The East London Parkinson Disease Project: Higher Immune Activation found in Patients with Parkinson’s Disease Dementia from a Diverse Population
Objective: The scope of this work was to characterise the B-cell receptor repertoire of patients with Parkinson’s disease with dementia (PDD), cognitively resilient (PDR) and…Personality Traits and Neuropsychiatric Assessment in De Novo, Clinically Established Body-First and Brain-First Parkinson’s Disease
Objective: To assess and compare personality profiles and psychiatric symptoms in de-novo clinically-established body-first and brain-first PD. Background: Body-first and brain-first have recently been proposed…Cognitive Biases in Movement Disorders: Implications for Clinical Decision-Making and Patient Perception of Symptoms
Objective: To explore how cognitive biases affect decision-making in patients with movement disorders, including misjudgments in symptom perception, risk-taking in treatment decisions and adherence to…Deep Brain Stimulation Increases Motivation to Obtain Larger Rewards in Parkinson’s Disease
Objective: To assess the effects of deep brain stimulation (DBS) on effort and reward processing for self-benefitting and prosocial behavior in people with Parkinson’s Disease…Retrospective Analysis of the Neuropsychological Profiles of Parkinson’s Disease Patients Selected for Deep Brain Stimulation Surgery in Hawaii.
Objective: To investigate the neuropsychological profiles of White, Japanese, and other Asian American or Pacific Islander (OAAPI) patients with Parkinson’s disease (PD) identified as candidates…Exploratory Longitudinal Analysis of Lifestyle and Parkinson’s Disease Symptoms
Objective: This study is an exploratory longitudinal analysis of lifestyle factors and Parkinson’s Disease (PD) symptoms that may inform targeted research into specific lifestyle interventions…
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