Development of a Beta-sensing Pathway in Deep brain stimulation to optimise utility of Local field potential recordings using the Percept system. (Newcastle Beta-sensing Algorithm – NBA)
Objective: To establish a pathway for utilisation of beta-sensing using the Percept technology which is applicable to real world clinical practice and optimises the utility…MDS PD e-Diary – a New Patient-Centered Digital Tool for People with Parkinson’s Disease
Objective: To describe the initial steps to develop a digital diary (e-Diary) for Parkinson’s disease (PD) – an MDS initiative of a novel patient-centered digital…Speech Biomarkers for Dysarthria in Parkinson’s Disease — Clinical Validation Across two Languages
Objective: To identify reliable speech biomarkers for assessing dysarthria in individuals with Parkinson's disease (PD) and ensuring their clinical validity across languages. Background: This study…Determining the optimal filtering method for the removal of gait-related movement artefacts from EEG acquired from People with Parkinson’s Disease
Objective: Development of an adaptive filtering algorithm to remove movement artefacts from EEG data acquired during a dual sensory-motor gait task when performed by People…Clinical differentiation between dystonic tremor and Parkinson’s disease based on tremor characteristics
Objective: We aimed to identify clinical characteristics that are useful for differentiating dystonic tremor (DT) and Parkinson's disease (PD). Background: DT is often challenging to…Genome-Wide Association Study revealing novel risk loci associated with Age at Onset of Parkinson’s Disease
Objective: This study aimed to determine single-nucleotide polymorphisms (SNPs) associated with AAO in Korean PD patients. Background: Age at onset (AAO) of Parkinson’s disease (PD)…Utility of using long-read whole genome sequencing to solve exome negative early-onset and familial Parkinson’s disease: a series of 106 individuals
Objective: (i) To identify complex variants usually not visible by short-read whole exome sequencing in known genes of Parkinson’s disease (PD) such as structural variants…Latent Genetic Architecture of Parkinson’s Disease Risk factors and Comorbidities
Objective: To comprehensively investigate the genetic relationship between Parkinson’s disease (PD), its risk factors, and comorbidities by constructing a factor model of the shared genetic…A UK-wide Effort for Identification of Loci for Autosomal Dominant Parkinson’s Disease
Objective: (i) To describe the demographic, clinical and genetic features of a large cohort of familial autosomal dominant Parkinson’s disease (PD) patients in the UK.(ii)…Real-Time Removal of Stimulus Artifact for Closed-Loop Deep Brain Stimulation by Synchronized Sample-And-Hold Artifact Blanking (SSAB): Verification in Animal Model
Objective: To develop and validate a real-time stimulus artifact removal analog front-end (AFE) by synchronized sample-and-hold artifact blanking (SSAB) technique with the Parkinsonian minipig model…
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