Pilot study of Phenotype of Antisense-Oligonucleotide-(ASO)-knockdown of Cerebral-Dopamine-Neurotrophic-Factor (CDNF) as Parkinson Disease model : implications for PD and related Dementia Therapeutics
Objective: Our objective is twofold: 1)to examine whether CDNF-ASO paradigm can induce a unique phenotype mimicking PD/PDD/LBW in the rodent species; 2) to evaluate whether…Coffee, smoking and aspirin are associated with age at onset and clinical severity in idiopathic Parkinson’s disease
Objective: To investigate a possible association between smoking, the consumption of caffeine and the use of aspirin on age at onset (AAO), motor and non-motor…Early Observations of Using a Chronically Implanted INS that can Sense Local Field Potentials in Movement Disorder Patients
Objective: The objective of this study is to report early findings from movement disorder and epilepsy patients that have been implanted with an INS device…Non-Tremor Motor Dysfunction is Associated with AD Biomarkers in Lewy Body Dementias
Objective: To investigate the clinical influence of Alzheimer’s disease (AD) co-pathology on motor features in Lewy Body Dementia (LBD). Background: There is considerable heterogeneity of…Analysis of effectiveness of Montreal Cognitive Assessment as cognitive evaluation method in low education level patients with Parkinson’s disease in the Brazilian Amazon.
Objective: To analyze the effectiveness of Montreal Cognitive Assessment (MoCA) to define dementia in low education level patients with PD in the Brazilian Amazon. Background:…A prospective study of Parkinson’s disease dementia – defining neuropsychological features
Objective: To identify neuropsychological predictors of conversion to dementia (PDD) in our cohort of Parkinson’s disease (PD) patients. Background: The heterogeneity of PD cognitive disorders…Using a Dopamine Genetic Risk Score to Predict Impulse Control Behaviours for Parkinson’s Disease Patients
Objective: The current study aimed to utilise a dopamine genetic risk score and objective laboratory-based behavioural measures of impulse control to identify Parkinson’s patients most…Blood-based circulating microRNAs for discriminating between Parkinson’s disease subtypes
Objective: The aim of this study was to establish candidate blood miRNAs biomarkers for PD by comparing differences in miRNAs expression between distinct PD subtypes. Background: Blood…Comprehensive analysis of PRKN in a large Parkinson’s Disease cohort identifies causative mutations and validates population scale screening by microarray
Objective: To screen for PRKN mutations at the population scale. Background: PRKN mutations are the most common recessive cause of Parkinson’s disease (PD) and are…Double labeling alpha-synuclein in labial minor salivary glands in Parkinson’s disease and idiopathic RBD patients
Objective: To investigate the presence of α-Syn immunostaining in minor salivary gland biopsies (MSGB) from patients with idiopathic Parkinson's disease (PD), idiopathic Rapid Eye Movement…
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