Parkinson’s-disease risk variants are differentially associated with discrete phenotypic characteristics of Parkinson’s-disease at baseline.
Objective: Evaluate whether genetic risk variants for Parkinson’s disease discovered in case-control GWAS uniformly or differentially contribute to the clinical phenotype of PD. Background: Genetic…Monogenic Hub of the Global Parkinson’s Genetics Program (GP2): The 500-genomes pilot project
Objective: To identify novel monogenic causes of Parkinson’s disease (PD). Background: The Global Parkinson’s Genetics Program (GP2, http://gp2.org/) is an international collaborative effort that aims…Genetic factors associated with dementia in Parkinson’s disease in the Parkinson’s Incidence Cohorts Collaboration (PICC)
Objective: To evaluate the effect of genetic variants in β-glucocerebrosidase (GBA), apolipoprotein E (APOE), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) loci on the risk…Parkinson’s disease-linked LDL Receptor Related Protein 10 (LRP10) is implicated in regulation of the secretory and autophagy-lysosome pathways
Objective: We aim to investigate the potential roles of LRP10 defects in PD, PDD and DLB, focusing on two pathways known to be central in…Induction of Parkinsonian-like changes via targeted down-regulation of astrocytic glutamate transporter GLT-1 in the striatum
Objective: The aim was to explore the function and mechanism of astrocytic GLT-1 in PD-like changes. Background: Numerous researches suggest decreased expression of glutamate transporter-1…DO FREEZING OF GAIT AND GAIT AUTOMATICITY IN PARKINSON’S DISEASE SHARE THE SIMILAR NEURAL SUBSTRATE?
Objective: To verify if freezing of gait (FOG) in Parkinson’s disease (PD) and gait automaticity share a similar neural substrate. Background: FOG in PD may…Intrasubject subcortical quantitative referencing to make quantitative MRI sensitive to Parkinson’s disease
Objective: To assess the changes in R2* occurring in PD patients compared to controls, a multicenter transversal study was carried out in a large cohort of…Altered glymphatic function in Parkinson’s disease
Objective: To examine glymphatic function in Parkinson’s disease utilizing the “Diffusion Tensor Image Analysis aLong the Perivascular Space (DTI-ALPS)” method. Background: Dysfunction of glymphatic system…Neuroanatomical signatures of genetic risk for Parkinson’s Disease in healthy adults
Objective: To determine whether there is a relationship between genetic risk for Parkinson’s disease (PD) and brain structure in healthy adults. Background: PD pathology begins…Patient classification for adaptive deep brain stimulation
Objective: To explore a control theory modeling framework to classify which Parkinson’s disease patients may benefit from adaptive deep brain stimulation. Background: Deep brain stimulation…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.