Characterisation of the pharmacokinetic profile of amantadine in the common marmoset
Objective: To determine the pharmacokinetic (PK) profile of amantadine in the common marmoset (Callithrix jacchus). Background: Amantadine is currently approved for the treatment of L-3,4-dihydroxyphenylalanine…Trends in Physiotherapy Interventions and Medical Costs for Parkinson’s Disease in South Korea, 2011–2020
Objective: We analyzed trends in PT interventions and associated medical costs among South Korean patients with PD between 2011 and 2020. Background: Physiotherapy (PT), an…Efficacy and Safety of Controlled-Release Levodopa in Parkinson’s Disease: a Systematic Review and Meta-Analysis
Objective: To evaluate the efficacy and safety of controlled-release levodopa (CRLD) compared with standard release levodopa (SRLD) in patients with Parkinson’s Disease (PD) and motor…The international validation of the “Stepped Care” toolkit for comprehensive real life clinical care: bridging massive unmet need in care of Parkinson’s disease.
Objective: To conduct a cognitive pretesting of a global, cross-cultural, multicentre (14 countries) Stepped Care clinical toolkit. The questionnaire is completed by the healthcare professional…Opicapone Reduces Homocysteine Levels in Patients with Parkinson’s Disease Treated with Levodopa Gel Infusion
Objective: Our study aims to assess the effect of an add-on treatment with catechol-O-methyl transferase (COMT) inhibitor, opicapone, on the plasmatic levels of homocysteine (HCY)…Association between statin use and mortality in Parkinson’s disease
Objective: To investigate whether usage of statin is associated with decreased mortality in Parkinson’s disease (PD). Background: Large-scale genome sequencing studies of PD have identified…iPLA2β controls ER-mitochondria tethering and Ca2+ transfer in Parkinson’s disease
Objective: In this study, we aimed to investigate whether Parkinson's disease (PD) associated calcium-independent phospholipase A2β (iPLA2β) regulates the integrity and functions of endoplasmic reticulum…Transcriptomic and Proteomic Profiling for Effective Deep Brain Stimulation in Parkinson’s Disease
Objective: To determine whether transcriptomic and proteomic changes predict better motor outcomes after deep brain stimulation (DBS) surgery in Parkinson’s disease (PD). Background: DBS is…Developing a Supervised Machine Learning Model for Long-Term Cognitive Status Prediction in Parkinson Disease
Objective: The study aims to develop a supervised machine learning (ML) model to predict long-term cognitive outcome in patients with Parkinson disease (PD). Background: Cognitive…A Kinematic and fMRI Study of the Neural Correlates of Bradykinesia in Parkinson’s Disease
Objective: This study aimed at investigating the neural and kinematic correlates of bradykinesia during hand-tapping in people with Parkinson’s disease (pwPD) relative to healthy controls.…
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