Comprehensive Multi-Platform Proteomic Analysis Identifies Novel Biomarkers for Parkinson’s Disease Diagnosis and Progression Monitoring
Objective: To replicate existing and identify novel protein biomarkers for PD diagnosis and progression. Background: Parkinson's disease (PD) lacks reliable biomarkers for early diagnosis and…Staging Disease Progression from Prodromal to Overt Stage of Alpha-synucleinopathies
Objective: To compute a disease progression model of the prodromal to overt synucleinopathy continuum, usable at single subject level. Background: Progression milestones to stage patients…Parkinson’s disease Symptoms Mitigated by Photobiomodulation: The Potential of the Tryptophan Kynurenine Ratio as a Marker for Responsiveness to Therapy.
Objective: To determine the potential of the tryptophan:kynurenine ratio (trp/kyn) as a marker for the responsiveness of Parkinson’s symptoms to treatment by photobiomodulation Background: The…Real world application of alpha-synuclein skin biopsy in the diagnosis of synucleinopathies at a tertiary care center
Objective: The goal of this study is to review the real-world application of alpha-synuclein skin biopsy at a tertiary care center. Background: Synucleniopathies including Parkinson’s…Digital measurement of ocular microtremor in Parkinson’s Disease: Analytical and clinical validation
Objective: This pilot study examined the analytical and clinical validation of OMT measurement via the iTremor ONE device in PwPD. Background: Ocular microtremor (OMT) is…Role of APOE Polymorphism and CSF Markers of AD Co-Pathology in the Cognitive Trajectories of Sporadic and Genetic Parkinson’s Disease: A Longitudinal Cohort Study
Objective: To evaluate if APOE genotype and CSF biomarkers of AD co-pathology are associated with distinct rates of cognitive decline in PD subtypes. Background: Cognitive…Cognitive Assessment in Parkinson’s Disease: A Mixed Methods Study of Current Neuropsychology Practices in Australia
Objective: To investigate the role of neuropsychologists, and their current practices for assessing cognition in Parkinson’s disease (PD). Background: Diagnosis and evaluation of cognitive disorders…Changes in Cognitive Function with Deep Brain Stimulation in PD patients with and without Freezing of Gait
Objective: To determine if deep brain stimulation (DBS) changes cognitive function in Parkinson’s Disease (PD), and if these cognitive changes may relate to gait dysfunction…Variations of Self-Perceived Cognitive Changes by Ethnicity in Parkinson’s Disease Patients
Objective: To study perceptions of cognitive function across ethnic groups by comparing a subjective rating with an objective assessment for patients with PD (PWP). Background:…A 6-Year Longitudinal Analysis from the Parkinson’s Progression Markers Initiative on Non-Motor Symptom Severity and Progression in GBA1-associated vs. sporadic Parkinson’s Disease
Objective: To compare GBA1-associated PD and sporadic PD progression based on NMS severity, using data from the Parkinson’s Progression Markers Initiative (PPMI) (https://www.ppmi-info.org) Background: Parkinson’s…
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