LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Pathologic Alpha-Synuclein: Clinical and Biomarker Characterization
Objective: To compare clinical and biomarker features and rate of progression among LRRK2-associated parkinsonism cases with and without in vivo evidence of pathologic alpha-synuclein (asyn)…Functionality Analysis of Immunoregulatory Cells Stimulated with Dopaminergic Agonists in People Living with Parkinson’s Disease
Objective: To evaluate the effect of dopaminergic agonists (DA) on the activation and functionality of regulatory cells in People living with Parkinson's Disease (PwP). Background:…Early GBA-Related Parkinson’s Disease has a Distinct Clinical Phenotype and Cholinergic Innervation
Objective: This study aims to characterize the clinical features and cholinergic innervation of early Parkinson’s disease (PD) patients with GBA mutations (GBA-PD). Background: The GBA-PD…Synaptic Density Loss in Parkinson’s Disease Independent of Age: Preliminary Findings using [18F]SynVesT-1 PET Tracer
Objective: To determine whether synaptic density differs in the brain of people with Parkinson’s disease and healthy controls using the [18F]-SynVesT-1 PET tracer. Background: The…From Images to Insights: Subtyping Parkinson’s Disease Using Unsupervised Learning on MRI Data
Objective: To explore the heterogeneity of Parkinson's disease (PD) using unsupervised clustering of neuroimaging data, aiming to identify distinct subtypes based on volumetric features. Background:…Regional Brain Volume Differences Across PD Clinical Subtypes
Objective: To investigate brain morphometric differences across Parkinson disease (PD) clinical subtypes. Background: We developed a PD subtype classification with three subtypes that includes motor…Deep brain stimulation Intraoperative imaging: False errors in the era of artificial intelligence
Objective: To assess the precision of Deep Brain Stimulation (DBS) electrode placement within Subthalamic nucleus (STN) using Advanced Imaging and artificial intelligence, considering the challenges…Deposition of phosphorylated TDP-43 around the tip of deep brain stimulation leads
Objective: The objective of this study is to investigate the depositions of abnormal proteins, including phosphorylated tau (p-tau) and phosphorylated transactivation response DNA-binding protein of…Evaluation of the results of neuromodulation of the Subthalamic Nucleus (STN) in patients with Parkinson’s Disease (PD) depending on the anesthesia used during stereotactic electrode implantation.
Objective: Comparison of the efficacy of STN neuromodulation after surgical intervention with Monitored Anesthesia Care (MAC) and using general anesthesia (GA). Background: The effectiveness of…MRgFUS thalamotomy for tremor-predominant Parkinson´s disease: a single-center prospective study
Objective: To examine the clinical outcomes and their relationship with lesion characteristics at 6-month follow-up in TDPD patients Background: Clinical outcomes and lesion features after…
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