Classify Parkinson’s Disease with Mild Cognitive Impairment: Machine Learning Approach
Objective: To determine how multimodal neuroimaging data can contribute to the classification of Parkinson’s disease (PD) patients with mild cognitive impairment (MCI) from PD without…Progression of dopaminergic and serotonergic dysfunction related to motor and nonmotor manifestations in apathetic and non-apathetic parkinsonian patients: a 4-year longitudinal double-tracer PET study
Objective: To investigate the progression of dopaminergic and serotonergic dysfunction and their relation to motor and nonmotor impairment in parkinsonian patients with or without apathy,…Study of cardiac sympathetic denervation by 18F-FDOPA PET-CT Imaging in early Parkinson disease (EPD) and Atypical parkinsonian syndromes (APS)
Objective: To evaluate utility of l-3,4-dihydroxy-6-[18F] fluoro-phenylalanine (18F-FDOPA) PET-CT imaging for cardiac sympathetic denervation in conjunction with nigrostriatal imaging in patients with early Parkinson disease (EPD) and Atypical…Relative Preservation of Serotonergic Function Increases Response to Treatment in Early PD
Objective: To investigate interactions between the serotonergic and dopaminergic systems in early PD as related to (i) response to treatment and (ii) dopamine (DA) release,…Correlating subcortical structure and function in idiopathic Parkinson’s disease: A cross-sectional morphometric and [18F]-DOPA PET study
Objective: To investigate whether the local geometric changes in the subcortical structures of patients with idiopathic Parkinson’s disease correlate with dopaminergic terminal functional integrity within…Multiple System Atrophy: phenotypic spectrum approach coupled with brain FDG PET
Objective: This study attempts to identify different phenotypes of patients with MSA and to describe corresponding brain 18-FDG Positron Emission Tomography (PET) patterns. Background: In…Imaging Brain Insulin Resistance in Parkinson’s Disease using [¹⁸F]FDG-PET
Objective: To obtain a glucose brain uptake survey of Parkinson's Disease (PD) patients with or without insulin resistance (IR). Background: IR is common in PD…Potential involvement of the caudate nucleus in GBA-associated Parkinson’s disease
Objective: Multimodal functional assessment of striatocortical loop integrity in Parkinson’s Disease (PD) patients with and without GBA variants Background: Biallelic GBA mutations provoke the lysosomal…Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
Objective: To investigate the potential beneficial effects of estrogen on nigrostriatal dopaminergic neuron degeneration in postmenopausal drug-naïve Parkinson’s disease. Background: Epidemiologic studies have revealed that…“Brain-first” vs. “body-first” Parkinson’s disease is determined by RBD-status – a multi-modality imaging study
Objective: In a multi-modality imaging study, we test the hypothesis that Parkinson’s disease (PD) can be divided into two strikingly distinct phenotypes: (1) PD patients,…
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