Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Systemic Inflammation and Cerebral Small Vessel Disease in Progressive Supranuclear Palsy
Objective: To assess the cerebral small vessel disease (CSVD) burden in progressive supranuclear palsy (PSP) and examine the relationships among peripheral inflammatory markers, CSVD imaging…Coupling of Cholinergic and Dopaminergic Terminal Loss in Progressive Supranuclear Palsy: A Multimodal [18F]FEOBV and [11C]PE2I Study
Objective: To describe the relationships between dopaminergic and cholinergic terminal deficits in Progressive Supranuclear Palsy (PSP) relative to age-matched Normal controls (NC). Background: There is…Plasma Proteomics in PSP
Objective: We implemented an unbiased proximity extension proteomics assay to identify novel plasma PSP biomarkers. Background: Blood-based biomarkers can help to support non-invasive early diagnosis…Diagnostic Utility of Routine 1.5T Brainstem Planimetry in Parkinsonism: Evidence from a Vietnamese Cohort
Objective: To compare absolute versus ratio brainstem planimetric measures on routine 1.5T MRI and to identify the best-performing metrics for differentiating PSP and MSA in…Real-World Survival, Healthcare Access, and Medication Patterns in Atypical Parkinsonian Disorders: A Multi-System EHR Analysis
Objective: To assess regional prevalence, demographics, survival, neurology access, and medication utilization in atypical parkinsonian disorders. Background: Progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and…Cholinergic Systems Changes Associated with Freezing of Gait in Progressive Supranuclear Palsy
Objective: To investigate whether distinctive cholinergic system changes are associated with FoG in PSP patients. Background: Freezing of gait (FoG) is a profound mobility disturbance…Sleep symptoms in people with Progressive Supranuclear Palsy in Argentina
Objective: To report sleep features and symptoms in a longitudinal prospective cohort of people with PSP from Argentina (CAITauP cohort). Background: Progressive supranuclear palsy (PSP),…Early Clinical Characteristics of Pathologically Confirmed Progressive Supranuclear Palsy and Corticobasal Degeneration
Objective: This study aimed to characterize the early clinical features of PSP and CBD to inform clinicians on diagnostic assessment and management strategies. Background: Although…Clinical Markers of Monogenic Mimics in Atypical Parkinsonism: Findings From a 150-Patient Series
Objective: We aimed to (1) define the yield and spectrum of genetic findings in an unselected Atypical Parkinsonism (AP) series and (2) identify clinical markers…
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