Can we stage tau pathology in PSP?
Objective: To evaluate distribution pattern of tau pathology in different PSP clinical subtypes and develop a staging system. Background: Progressive supranuclear palsy (PSP) is a…Identification and characterization of anti-prionic compounds that disassemble Tau prions as a novel therapeutic approach for tauopathies
Objective: Stabilization of monomeric Tau protein by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for tauopathies. Background: Tauopathies…Successful treatment of incessant purposeless groaning in Progressive Supranuclear Palsy with Pimozide
Objective: Evaluation of therapeutic options for a patient of Progressive Supranuclear Palsy (PSP) presenting with incessant purposeless groaning. Background: PSP is a neurodegenerative disorder characterized…Mass spectrometry-based proteomics brain analysis to distinguish between Parkinson syndromes
Objective: To address the gap existing during clinical diagnosis in differentiating among various forms of Parkinson syndrome (PS) by using mass spectrometry (MS)-based brain proteomics.…Progressive supra nuclear palsy phenotype with idiopathic basal ganglia calcification
Objective: To present a rare case of progressive supra-nuclear gaze palsy (PSP) in a patient with idiopathic basal ganglia calcification in a patient with idiopathic…Automated pattern based classification in neuropathology proven parkinsonism
Objective: In patients with parkinsonism and uncertain differential diagnosis, an automated image-based algorithm can help to distinguish idiopathic Parkinson’s disease (IPD) from atypical parkinsonian syndromes…The Progressive Supranuclear Palsy Clinical Deficits Scale
Objective: To develop a scale to monitor clinical deficits in patients with Progressive Supranuclear Palsy across its broad phenotypes. Background: There is currently no undisputed,…Automated classification of neurodegenerative parkinsonian syndromes using multimodal magnetic resonance imaging in a clinical setting
Objective: To evaluate the accuracy for the categorization of parkinsonian syndromes of a machine learning algorithm trained with a research cohort and tested on an…Chromogranin B in cerebrospinal fluid as a novel biomarker for Progressive supranuclear palsy
Objective: To identify the biomarker associated with progressive supranuclear palsy (PSP) for better understanding of a pathophysiology and clinical diagnosis. Background: PSP is one of…Clinical features and natural course of corticobasal degeneration and progressive supranuclear palsy presenting as corticobasal syndrome
Objective: To compare clinical features and natural course of corticobasal degeneration (CBD) presenting as corticobasal syndrome (CBD-CBS) and progressive supranuclear palsy presenting as corticobasal syndrome…
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