Diagnostic Utility of Routine 1.5T Brainstem Planimetry in Parkinsonism: Evidence from a Vietnamese Cohort
Objective: To compare absolute versus ratio brainstem planimetric measures on routine 1.5T MRI and to identify the best-performing metrics for differentiating PSP and MSA in…Real-World Survival, Healthcare Access, and Medication Patterns in Atypical Parkinsonian Disorders: A Multi-System EHR Analysis
Objective: To assess regional prevalence, demographics, survival, neurology access, and medication utilization in atypical parkinsonian disorders. Background: Progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and…Cholinergic Systems Changes Associated with Freezing of Gait in Progressive Supranuclear Palsy
Objective: To investigate whether distinctive cholinergic system changes are associated with FoG in PSP patients. Background: Freezing of gait (FoG) is a profound mobility disturbance…Sleep symptoms in people with Progressive Supranuclear Palsy in Argentina
Objective: To report sleep features and symptoms in a longitudinal prospective cohort of people with PSP from Argentina (CAITauP cohort). Background: Progressive supranuclear palsy (PSP),…Early Clinical Characteristics of Pathologically Confirmed Progressive Supranuclear Palsy and Corticobasal Degeneration
Objective: This study aimed to characterize the early clinical features of PSP and CBD to inform clinicians on diagnostic assessment and management strategies. Background: Although…Clinical Markers of Monogenic Mimics in Atypical Parkinsonism: Findings From a 150-Patient Series
Objective: We aimed to (1) define the yield and spectrum of genetic findings in an unselected Atypical Parkinsonism (AP) series and (2) identify clinical markers…Determinants of Re-diagnosis of Parkinson’s Disease to Atypical Parkinsonism: Results from the Tracking Parkinson’s Cohort (PRoBAND) and Oxford Parkinson’s Discovery Cohort (OPDC) Cohorts
Objective: We aim to identify the clinical and biomarker features which best predict re-diagnosis to a Parkinson plus syndrome (PPS) in those initially diagnosed with…Phenotypic and Genotypic Spectrum of MAPT-associated Parkinsonism in a Multi-ethnic Malaysian Cohort
Objective: To describe the phenotypic continuum and genotypic spectrum of microtubule-associated protein tau (MAPT)-associated parkinsonism in a multi-ethnic Malaysian cohort. Background: Carriers of pathogenic MAPT…Exploratory Results From a Phase 1 Study of NIO752 in Progressive Supranuclear Palsy Supporting Further Clinical Studies
Objective: To report exploratory analyses of biomarker and clinical outcomes from a first-in-human study of NIO752 in progressive supranuclear palsy (PSP) and provide rationale for…A Systematic Review and Meta-Analysis on Cognitive and Behavioral Impairments in Primary Tauopathies
Objective: Synthesize available evidence on cognitive, behavioral, and clinical severity measures in PSP and CBS. Background: Cognitive and behavioral impairment are key sources of disability in…
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