Phenotypic Evolution from Nonfluent PPA to PSP
Objective: Progressive Supranuclear Palsy (PSP) and Nonfluent Primary Progressive Aphasia (nfvPPA) are clinicopathological entities within the 4-repeat tauopathy (4R tauopathy) spectrum. Increasing evidence suggests that…MobilityAPP: A randomized-controlled trial evaluating gait-focused physiotherapy in Parkinson’s disease and atypical parkinsonian syndromes
Objective: Effect on gait and balance of gait-focused physiotherapy compared to standard-of-care physiotherapy in patients with MSA, PSP and PD. Background: Physiotherapy is a crucial element…Early Overlap of Corticobasal Syndrome and Richardson Syndrome in Corticobasal Degeneration: Evidence from 252 Autopsy-Confirmed Cases
Objective: This study aimed to identify early clinical phenotypes of corticobasal degeneration (CBD) using unsupervised analysis of a large clinicopathologic dataset. Background: Early diagnosis of…QSM-Based Substantia Nigra Volumetry Improves Differentiation of Progressive Supranuclear Palsy from Parkinson’s Disease and Multiple System Atrophy
Objective: To evaluate whether quantitative susceptibility mapping (QSM)-based substantia nigra (SN) volumetry improves differentiation of progressive supranuclear palsy (PSP) from Parkinson’s disease (PD) and multiple…Sex comparisons for co-pathologies and clinical phenotypes in autopsy-confirmed four-repeat tauopathies
Objective: To assess whether co-pathologies and clinical phenotypes in people with four-repeat tauopathies (progressive supranuclear palsy [PSP], corticobasal degeneration [CBD]) differ by sex. Background: PSP…Utility of the Short Cognitive and Neuropsychiatric Assessment Scale (ShoCo) in a Multiethnic Asian Cohort of Patients with Progressive Supranuclear Palsy
Objective: To assess the clinical utility of the Short Cognitive and Neuropsychiatric Assessment (ShoCo) scale in a multi-ethnic Malaysian cohort of patients with progressive supranuclear…Dysphagia and Oropharyngeal Freezing in Progressive Supranuclear Palsy
Objective: To investigate the characteristics and mechanism of dysphagia in patients with Progressive Supranuclear Palsy(PSP). Background: Up to 79% of patients with PSP suffer from…Clinical Analysis of Progressive Supranuclear Palsy in Sri Lanka: Preliminary Results from a Cross-Sectional Collaborative Study with Global Parkinson’s Genetic Program (GP2)
Objective: Characterize the clinical phenotype of a Sri Lankan Progressive Supranuclear Palsy (PSP) cohort and identify correlations between severity with cognitive impairment and functional status.…Remotely Administered Reaction Time Correlates in Progressive Supranuclear Palsy
Objective: To evaluate the cross-sectional associations of remotely administered reaction time (RT) in PSP. Background: PSP causes cognitive dysfunction, with severe deficits in psychomotor speed,…Data-driven operational definition of square-wave jerks to optimize diagnostic discrimination of progressive supranuclear palsy
Objective: To use a data-driven approach to create an optimal SWJ definition and to assess its diagnostic utility in PSP. Background: The Movement Disorder Society…
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