Quercetin administration abrogates the Parkinson’s disease (PD)-like motor and non-motor symptoms and attenuates the behavioral, neurochemical and biochemical deficits induced by rotenone toxicity in rats
Objective: The present study was carried out to investigate the preventive and therapeutic effects of quercetin (a flavonol) against rotenone-induced neurotoxicity. Background: Rotenone (pesticide) induced…Chlorogenic acid and Trianthema portulacastrum combinational therapy mitigates rotenone induced Parkinsonism in wistar rats
Objective: The present study was aimed to explore the synergistic neuroprotective effect of combination of natural phenolic compound, i. e., chlorogenic acid, and butanol extract…Low doses of scopolamine exacerbates dementia among Drosophila with Parkinson’s disease pathophysiology
Objective: To assess the non-inducing doses of scopolamine (SCL) on the memory function of Drosophila previously induced with Parkinson's disease phenotype. Background: A large body…The role of lipid metabolism in mouse models of Parkinson’s disease
Objective: To investigate the role of lipid metabolism and the effect of blocking carnitine palmitoyl-transferase 1 (CPT1) in toxic and genetically mouse models of Parkinson’s…The Role of Environmental Toxins (Rotenone) in Parkinson’s Disease
Objective: Learn the role of environmental toxins - rotenone in development of Parkinson's disease Background: Rotenone is a powerful pesticide. It is also a lipophilic…Exposed-Only Analysis of Gene-Pesticide Interaction in Parkinson’s Disease (PD)
Objective: Assess gene-pesticide associations with PD using an exposed-only design in a highly exposed cohort. Background: Pesticide use is associated with an increased risk of…Neuroprotective effects of coffee ingredients against rotenone-induced neurodegeneration in parkinsonian model
Objective: In this study, we examined neuroprotective effects of coffee ingredients, caffeic acid (CA) and chlorogenic acid (CGA), against rotenone-induced neurodegeneration using primary cultured cells…Neuroprotective Effects of A Combination of Curcumin and Mucuna Prurience in Rotenone Induced Mice Model of Parkinson’s Disease
Objective: In the current study we have evaluated possible synergistic neuroprotective effect of two Poly-Phenols from Curcumin and Mucuna Prurience. The combine treatment of Curcumin…Inhibition of HDAC4 attenuates rotenone-induced abnormal increase of α-synuclein levels and affects autophagic flux in human dopaminergic SH-SY5Y cells
Objective: To explore the effects of selective inhibition of HDAC4, on levels of α-syn and autophagy-related proteins in PD. To discuss the mechanism for the…Rose Anthocyanins protect against Parkinson’s pathophysiology: Behavioral and biochemical changes in young Drosophila
Objective: To test the hypothesis that Rose Anthocyanins, owing to their biological properties in vitro, protect against Parkinson’s pathophysiology in young Drosophila melanogaster. Background: Anthocyanins…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.